AI Article Synopsis
- This text discusses the complexities of understanding phenotypes and genetic factors related to metabolic syndrome (MetS), highlighting the difficulties in pinpointing their contributions to complex diseases.* -
- It emphasizes the advancements in systems genomics that are necessary for identifying and evaluating the functional roles of traits linked to MetS, especially in relation to insulin resistance and its associated conditions like obesity and diabetes.* -
- The commentary argues for a deeper exploration of the molecular mechanisms of MetS in order to better understand the genetic determinants involved in lipodystrophy-related diabetes mellitus.*
Article Abstract
Understanding phenotypes and their genetic determinants for metabolic syndrome (MetS) has been quite challenging. With the advent of systems genomic approaches, there is a need to decipher methods for identification and evaluating the functional role of phenotypic traits associated with complex diseases, such as MetS. The monogenic syndromes of lipodystrophy are well understood, but the molecular pathophysiology of insulin resistance (IR) underpinning the obesity, diabetes mellitus, and dyslipidemia is not well deciphered. In this commentary, we argue the role of pathophysiology of MetS, and its effects into possible understanding of genetic determinants associated with lipodystrophy-mediated diabetes mellitus.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163883 | PMC |
| http://dx.doi.org/10.3390/biom8030047 | DOI Listing |
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