AI Article Synopsis
- Plasma cyclic GMP (cGMP) levels were significantly elevated in untreated acute leukemia patients compared to normal subjects, while cyclic AMP levels remained similar to those of healthy individuals.
- In patients who achieved complete remission, cGMP levels returned to normal and stayed in that range throughout the remission period.
- An increase in cGMP levels during relapse indicated that monitoring these levels could be important for tracking patient response to treatment.
Article Abstract
To verify the clinical usefulness of plasma cyclic nucleotide determination as a tumor marker, levels were measured in 52 normal subjects and in 106 acute leukemia patients. In untreated patients plasma cyclic GMP (cGMP) levels were markedly elevated, whereas cyclic AMP levels did not significantly differ from those of normal subjects. Plasma cGMP levels normalized in all patients who attained complete remission and remained in the normal range during all the remission period. In the patients who relapsed, an early increase in cGMP levels to the pretreatment values was observed, thus suggesting that their determination may be of clinical relevance in monitoring the patients' response to treatment.
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