Role of myeloperoxidase in early diagnosis of acute myocardial infarction in patients admitted with chest pain.

J Immunoassay Immunochem

d Clinical Pathology Department, Faculty of Medicine , Al-Azhar University, New Damietta , Egypt.

Published: August 2018

AI Article Synopsis

  • * The study compared MPO with other markers like creatine kinase (CK) MB and Troponin I (cTn I), finding that MPO had a high diagnostic efficiency of 82.5% within the first 6 hours after chest pain onset.
  • * A predictive score combining the levels of MPO, CK-MB, and TnI accurately identified 91% of AMI patients, highlighting that using these biomarkers together enhances the early diagnosis of AMI.

Article Abstract

Myeloperoxidase (MPO) is an inflammatory marker, elevated in acute coronary syndromes (ACSs), especially in acute myocardial infarction (AMI) cases. This study aimed to evaluate the diagnostic power of MPO in AMI patients. MPO, creatine kinase (CK) MB, and Troponin I (cTn I) were performed for all study patients. Area under the curves (AUCs) and 95% confidence intervals (CI); P values of baseline levels of MPO for discriminating AMI patients from noncoronary chest pain (NCCP) patients, stable angina (SA) patients, and unstable angina (UA) patients were 0.91, 95% CI: 0.82-0.99; P < 0.0001, 0.87, 95% CI: 0.77-0.98; P < 0.0001, and 0.72, 95% CI: 0.58-0.85; P = 0.002, respectively. For diagnosing AMI from ACS patients, MPO was the most efficient marker than others markers with efficiency 82.5% within 0-6 hr after the onset time of chest pain. A predictive score that depends on a combination of baseline levels of three markers (MPO, CK-MB, and TnI) was correctly discriminated 91% of the AMI patients with high specificity 76%. In conclusion, the use of baseline levels of three biomarkers in combination could confer the information that is required for best available early diagnosis of AMI.

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http://dx.doi.org/10.1080/15321819.2018.1492423DOI Listing

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