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Minimizing blood sampling in preterm infants.
Cochrane Database Syst Rev
November 2024
Cochrane Sweden, Department of Research, Development, Education and Innovation; Paediatrics, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden, Lund University, Skåne University Hospital, Lund, Sweden.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of different strategies to minimize blood sampling in preterm infants.
View Article and Find Full Text PDFEpidemiology and disease characteristics of myelofibrosis: a comparative analysis between Italy and global perspectives.
Front Oncol
July 2024
Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Myelofibrosis (MF) is a clonal disorder of hematopoietic stem cells characterized by altered bone marrow function and fibrosis. The aim of this narrative review is to report on the most recent epidemiologic data and to discuss features of MF and current strategies for the management of this condition in clinical practice. MF features covered by our review will include: characteristics of patients with MF; myeloproliferative and myelodepletive phenotypes; MF-associated thrombosis and bleeding; risk of infections; prefibrotic and overt PMF; secondary MF.
View Article and Find Full Text PDFModeling of Parkinson's Disease Progression and Implications for Detection of Disease Modification in Treatment Trials.
J Parkinsons Dis
September 2024
Roche Pharma Research and Early Development (pRED), Roche Innovation Center, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Background: Objectively measuring Parkinson's disease (PD) signs and symptoms over time is critical for the successful development of treatments aimed at halting the disease progression of people with PD.
Objective: To create a clinical trial simulation tool that characterizes the natural history of PD progression and enables a data-driven design of randomized controlled studies testing potential disease-modifying treatments (DMT) in early-stage PD.
Methods: Data from the Parkinson's Progression Markers Initiative (PPMI) were analyzed with nonlinear mixed-effect modeling techniques to characterize the progression of MDS-UPDRS part I (non-motor aspects of experiences of daily living), part II (motor aspects of experiences of daily living), and part III (motor signs).
Indoor air: Guidelines, policies, and regulation.
J Allergy Clin Immunol
October 2024
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass.
Shoulder function following oncoplastic breast conserving surgery-a narrative review.
Gland Surg
May 2024
Department of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, Denmark.
Background And Objective: The high prevalence of breast cancer survivors makes it very relevant to investigate late morbidity following the treatment. Oncoplastic breast conserving surgery (OPS) has gained great popularity over the past years, and evidence-based knowledge suggest better prognosis for treatment with breast conserving surgery (BCS) compared to mastectomy. The aim was to investigate if OPS causes late effects on an acceptable level compared to what we know about breast surgery causing late effects.
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