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A novel hybrid model for air quality prediction via dimension reduction and error correction techniques.
Environ Monit Assess
December 2024
School of Big Data and Statistics, Anhui University, Hefei, 230601, Anhui, China.
The monitoring of air pollution through the air quality index (AQI) is a fundamental tool in ensuring public health protection. Accurate prediction of air quality is necessary for the timely implementation of measures to control and manage air pollution, thereby mitigating its detrimental impact on human health. A novel hybrid prediction model is proposed, which is EMD-KMC-EC-SSA-VMD-LSTM.
View Article and Find Full Text PDFMicrobiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery.
Immunotargets Ther
December 2024
Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC, 27707, USA.
Background: Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with numerous risk factors contributing to its development. Recent research has illuminated the significant role of the gut microbiota in CRC pathogenesis, identifying various microbial antigens as potential targets for vaccine development.
Aim: This review aimed at exploring the potential sources of microbial antigens that could be harnessed to create effective CRC vaccines and understand the role of microbiome-CRC interactions in carcinogenesis.
Chimeric antigen receptor natural killer cell therapy: A systematic review of preclinical studies for hematologic and solid malignancies.
Hum Immunol
December 2024
Research Center for Social Determinants of Health,Research institute for metabolic and obesity disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
Advancements in the field of CAR-T therapy have brought about a revolution in the treatment of numerous types of cancer in the past ten years. However, despite the remarkable success achieved thus far, certain barriers impede the widespread implementation of this therapy such as intricate manufacturing processes and treatment-associated toxicities. As an alternative, chimeric antigen receptor-engineered natural killer cell (CAR-NK) therapy presents a viable opportunity for a simpler and more cost-effective "off-the-shelf" treatment option, which is likely to result in fewer adverse reactions.
View Article and Find Full Text PDFLurbinectedin is an effective alternative to platinum rechallenge and may restore platinum sensitivity in patients with sensitive relapsed small cell lung cancer.
Expert Rev Anticancer Ther
December 2024
Medical Department, PharmaMar, Madrid, Spain.
Introduction: Platinum rechallenge is recommended for patients with small cell lung cancer (SCLC) who relapse ≥90 days after completing first-line chemotherapy, although it may not always be the most suitable option.
Areas Covered: Articles for review were identified via PubMed and ClinicalTrials.gov searches, supplemented with non-indexed publications (e.
Modeling the extra column volume of a micro simulated moving bed chromatography system: Introducing the equivalent radial flow rate distribution.
J Chromatogr A
January 2025
Institute of Functional Interfaces, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany. Electronic address:
Recently, the focus in chromatography model development has expanded to include the modeling of extra column volume (ECV), particularly in small- and lab-scale systems where ECV can constitute a significant portion of the total volume. Typically, ECV is modeled with 1D approaches, for example with combinations of dispersed plug flow reactors (DPFRs) and continuously stirred tank reactors (CSTRs). However, radial inhomogeneities in the ECV concentration profile necessitate higher-dimensional models for more accurate predictions.
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