AI Article Synopsis
- Bile acids are essential for lipid metabolism and absorption, with the ileal apical sodium-dependent bile acid transporter (ASBT) playing a key role in their reuptake and balance.
- Recent research has explored how ASBT is regulated and its connections to conditions like intestinal inflammation, cancer, diabetes, and high lipid levels.
- The findings suggest that targeting ASBT could be a promising therapeutic approach for addressing these health issues.
Article Abstract
Bile acids play critical roles in the regulation of metabolism and absorption of lipids. The ileal apical sodium-dependent bile acid transporter (ASBT) located at the enterocyte brush border is responsible for the reuptake of bile acids and the maintenance of bile acid homeostasis. Recently, a number of investigations have been made concerning the regulation and control of ASBT and the relationship between ASBT and intestinal inflammation, tumorigenesis, diabetes mellitus and hyperlipemia, which suggests ASBT as a potential therapeutic target of these diseases. In this review, advances in the study of above-mentioned issues were summarized.
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