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Platelet inhibition by hypochlorous acid involves cAMP signalling.
Cell Signal
December 2024
UCD School of Medicine, UCD Conway Institute, University College Dublin, Dublin 4, Belfield, Ireland; Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin D02 YN77, Ireland. Electronic address:
Hypochlorous acid (HOCl), made by neutrophil-derived myeloperoxidase, has been suggested to inhibit platelets, however, the mechanisms involved have not been described. Here we confirm that HOCl exposure changes platelet morphology and inhibits platelet spreading and aggregation. HOCl effects could be reversed by glutathione suggesting a role for cysteine oxidation.
View Article and Find Full Text PDFEfficacy of oral treprostinil for treating pulmonary arterial hypertension: a systematic review and meta-analysis.
Postepy Kardiol Interwencyjnej
September 2024
Department of Nephrology, The Fifth People's Hospital of Ganzhou, Ganzhou, China.
Introduction: Pulmonary arterial hypertension (PAH) is a progressive condition characterized by elevated blood pressure in the pulmonary arteries, leading to significant morbidity and mortality. Treprostinil, a synthetic analogue of prostacyclin, has emerged as a potential treatment option.
Aim: The efficacy and safety of oral treprostinil in PAH patients remain subjects of ongoing research.
Current Pharmaceutical Strategies in the Management of Persistent Pulmonary Hypertension of the Newborn (PPHN): A Comprehensive Review of Therapeutic Agents.
Cureus
September 2024
Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- * Current treatments for PPHN include inhaled nitric oxide, prostacyclin analogs, phosphodiesterase inhibitors, and endothelin receptor antagonists, with ECMO being used for the most severe cases.
- * The review emphasizes the need for improving timely diagnosis and treatment accessibility, while also exploring new therapies and the potential of personalized medicine to enhance outcomes for infants with PPHN.
NADPH Oxidase 4: Crucial for Endothelial Function under Hypoxia-Complementing Prostacyclin.
Antioxidants (Basel)
September 2024
Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, 01307 Dresden, Germany.
: The primary endothelial NADPH oxidase isoform 4 (NOX4) is notably induced during hypoxia, with emerging evidence suggesting its vasoprotective role through HO production. Therefore, we aimed to elucidate NOX4's significance in endothelial function under hypoxia. : Human vessels, in addition to murine vessels from mice, were explored.
View Article and Find Full Text PDFSignaling Paradigms of HS-Induced Vasodilation: A Comprehensive Review.
Antioxidants (Basel)
September 2024
Neuromuscular Rehabilitation Clinic Division, Clinical Emergency Hospital "Bagdasar-Arseni", 041915 Bucharest, Romania.
Article Synopsis
- * HS promotes vasodilation mainly by activating ATP-sensitive potassium channels and inhibiting L-type calcium channels, leading to more relaxed vascular smooth muscle cells and increased blood flow.
- * The gas also boosts the effects of cyclic guanosine monophosphate (cGMP) through the stimulation of soluble guanylyl cyclase and enhances nitric oxide availability, creating a synergistic effect that further supports blood vessel relaxation.
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