Here, we present new theory and law of longevity intended to evaluate fundamental factors that control lifespan. This theory is based on the fact that genes affecting host organism longevity are represented by subpopulations: genes of host eukaryotic cells, commensal microbiota, and non-living genetic elements. Based on Tetz's theory of longevity, we propose that lifespan and aging are defined by the accumulation of alterations over all genes of macroorganism and microbiome and the non-living genetic elements associated with them. Tetz's law of longevity states that longevity is limited by the accumulation of alterations to the limiting value that is not compatible with life. Based on theory and law, we also propose a novel model to calculate several parameters, including the rate of aging and the remaining lifespan of individuals. We suggest that this theory and model have explanatory and predictive potential to eukaryotic organisms, allowing the influence of diseases, medication, and medical procedures to be re-examined in relation to longevity. Such estimates also provide a framework to evaluate new fundamental aspects that control aging and lifespan.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208853 | PMC |
| http://dx.doi.org/10.1007/s12064-018-0267-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Climate change, migration, and health: perspectives from Latin America and the Caribbean.
Lancet Reg Health Am
December 2024
Latin American Centre of Excellence for Climate Change and Health, Universidad Peruana Cayetano Heredia, San Martín de Porres, 15102, Peru.
This article delves into the complex relationship between climate change, migration patterns, and health outcomes in Latin America and the Caribbean (LAC). While the severe impact of climate change on health in LAC is widely acknowledged, the article sheds light on the often-overlooked multiple effects on migration and the well-being of migrants. These impacts encompass poverty, food and water insecurity, and adverse physical and mental health outcomes.
View Article and Find Full Text PDFResearch on quantitative evaluation of medical insurance fraud supervision policy based on 'Antecedents-Process-Outcomes' framework.
PLoS One
January 2025
School of Management, Wuhan University of Technology, Wuhan, Hubei Province, China.
Fraud in medical insurance is a serious problem that threatens the safety and sustainability of medical insurance funds. The process of reducing or even eliminating the impact of fraud is related to maintaining the balance of payments for medical insurance funds and reforming the payment system based on total amount control. As a result of reviewing the policy background of medical insurance fraud in China, combined with the policy evaluation model in the area of public management, this paper develops a conceptual framework of 'Antecedents-Process-Outcomes' that emphasizes the fraud and governance of medical insurance funds.
View Article and Find Full Text PDFTowards Equitable Diabetes Care: A Global Perspective on Quality Measurement Exchange.
Health Syst Reform
December 2025
Department of Health Policy and Management, School of Public Health, Ben-Gurion University of the Negev, Beer Sheva, Israel.
In the pursuit of equitable diabetes care, international knowledge exchange (iKE) serves as a crucial mechanism for narrowing the gaps in quality within and between countries. Little is known about the process of quality measurement exchange among stakeholders from high-income countries (HICs), low- and middle-income countries (LMICs), and international organizations. This study aims to analyze recent international exchanges of quality measures in diabetes care and propose a framework for enhancing quality, focusing on LMICs.
View Article and Find Full Text PDFBootstrap Principle for the Spectrum and Scattering of Strings.
Phys Rev Lett
December 2024
Center for Cosmology and Particle Physics, Department of Physics, New York University, New York, New York 10003, USA.
We show that the Veneziano amplitude of string theory is the unique solution to an analytically solvable bootstrap problem. Uniqueness follows from two assumptions: faster than power-law falloff in high-energy scattering and the existence of some infinite sequence in momentum transfer at which higher-spin exchanges cancel. The string amplitude-including the mass spectrum-is an output of this bootstrap.
View Article and Find Full Text PDFWetting Phenomena: Line Tension and Gravitational Effect.
Phys Rev Lett
December 2024
Institute for Applied Materials - Microstructure Modelling and Simulation (IAM-MMS), Karlsruhe Institute of Technology (KIT), Strasse am Forum 7, 76131 Karlsruhe, Germany; Institute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany; and Institute of Digital Materials Science, Karlsruhe University of Applied Sciences, Moltkestrasse 30, 76133 Karlsruhe, Germany.
An apparent contact angle is formed when a droplet is deposited on a solid substrate. Young's law has been employed to describe the equilibrium contact angle. Often in experiments, the equilibrium contact angle deviates from Young's law and depends on the volume of the droplet, known as the line tension effect.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!