AI Article Synopsis
- The study analyzed the central nervous system of 15 sheep that showed signs of infection, specifically looking for cysts related to a certain parasite over a period from 2012 to 2016.
- Identifying the species involved was done using PCR and parasitological methods; cysts were found mainly in the cerebral tissue, with varying sizes and quantities across the sample.
- The findings highlighted the immune response in the sheep, indicating that particular cell types were active around the cysts, revealing important insights into how the sheep's immune system responds to the parasitic infection.*
Article Abstract
Introduction: This study consisted in histopathological and immunohistochemical examinations of the central nervous system of 15 sheep suspected of infection with . The sheep displayed compulsive circling and were submitted for necropsy in 2012-2016.
Material And Methods: Species identification was made on the basis of the PCR analysis and parasitological examination of the cysts.
Results: cysts were detected only in the cerebral tissue of 13 sheep and in the cerebral and cerebellar tissues of 2 animals. Out of the 33 parasite cysts, most (21.21%) were located in the right and left frontal lobes of the cerebrum. The largest cyst measured 6 × 5 cm and the smallest cyst was 2 × 2 cm in size. The highest and lowest numbers of scolices were 55 and 21, and the number of rostellar hooks ranged between 22 and 30. Histopathological examination revealed the presence of typical parasitic granulomatous inflammatory foci. Immunohistochemical staining showed that most common in the periphery of the parasite cysts were, in descending order by cell number, GFAP, CD163, CD3, and CD79α-positive cells.
Conclusion: The study confirms the role of cellular defence mechanisms in the pathogenesis of infection in sheep.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957459 | PMC |
| http://dx.doi.org/10.1515/jvetres-2018-0005 | DOI Listing |
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