AI Article Synopsis
- This study highlights the gap in data regarding co-infections in poultry and aims to address this issue through experimental research.* -
- Broiler birds were infected with both the H9N2 strain and low pathogenic avian influenza (LPAI) virus to analyze clinical effects, finding that co-infection resulted in increased severity of symptoms and reduced survival rates.* -
- The results suggest that the presence of one virus may enhance the replication of the other, leading to more severe health impacts for the birds, indicating a need for further understanding of these interactions in poultry disease management.*
Article Abstract
Introduction: Despite the advancements in the field, there is a lack of data when it comes to co-infections in poultry. Therefore, this study was designed to address this issue.
Material And Methods: Broiler birds were experimentally infected with (O78) and low pathogenic avian influenza (LPAI) strain, alone or in combination. The experimental groups were negative control.
Results: The infected birds showed most severe clinical signs in +LPAI group along with a significant decrease in weight and enhanced macroscopic and microscopic pathological lesions. The survival rate was 60%, 84%, and 100% in birds inoculated with +LPAI, , and LPAI virus alone, respectively. The results showed that experimental co-infection with and H9N2 strain of LPAI virus increased the severity of clinical signs, mortality rate, and gross lesions. The HI titre against LPAI virus infection in the co-infected group was significantly higher than the HI titre of LPAI group, which may indicate that may promote propagation of H9N2 LPAI virus by alteration of immune response.
Conclusion: The present study revealed that co-infection with and H9N2 LPAI virus caused more serious synergistic pathogenic effects and indicates the role of both pathogens as complicating factors in poultry infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894427 | PMC |
| http://dx.doi.org/10.1515/jvetres-2017-0035 | DOI Listing |
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