is an aerobic Gram-negative coccobacillus that is associated with hospital acquired pneumonia. There is increased reporting of emergent cases of community acquired multidrug resistance (MDR) associated with a higher mortality due to antibiotic resistance. Community acquired MDR pneumonia has not been reported in Malaysia. Here we report a case of a 19-year-old army officer who presented with fever and respiratory symptoms for 5 days. He had no known medical illness before and no history of hospitalization. Upon arrival, he was in septicaemic shock, requiring invasive ventilator support and renal replacement therapy in intensive care unit. Chest radiograph showed bilateral lung consolidations and bronchoscopy revealed haemoserous and greenish bronchiole secretion. He was treated with broad spectrum antibiotics and oseltamivir. Unfortunately he died on day 3 of hospital admission. His bronchial lavage culture came back positive for MDR . This case illustrates that clinicians need to be aware that MDR can cause severe community acquired pneumonia. We may need to consider this diagnosis in patients who do not respond to standard therapy.
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http://dx.doi.org/10.1016/j.rmcr.2018.05.019 | DOI Listing |
Front Cell Infect Microbiol
January 2025
Emergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Background: Community-acquired pneumonia (CAP) poses a significant health threat to the elderly population, leading to high morbidity and mortality rates. Serum ferritin, a critical indicator of iron metabolism, plays a pivotal role in inflammation and immune regulation. Nevertheless, its specific prognostic relevance in elderly patients with CAP remains unclear.
View Article and Find Full Text PDFJ Community Hosp Intern Med Perspect
January 2025
Internal Medicine Residency Program, Florida State University College of Medicine, Tallahassee, FL, USA.
Lymphogranuloma venereum (LGV) is a sexually transmitted infection typically caused by serovars L1-L3 of . These serovars are tissue-invasive with a preponderance for lymphatic spread and can be acquired via unprotected oral, anal, or vaginal sex. We present the case of a 23-year-old with a prior history of syphilis admitted with four weeks of progressively enlarging painful right cervical lymphadenopathy.
View Article and Find Full Text PDFSoft Matter
January 2025
Faculty of Physics, University of Vienna, Boltzmanngasse 5, Vienna 1090, Austria.
Particle-tracking microrheology probes the rheology of soft materials by accurately tracking an ensemble of embedded colloidal tracer particles. One-particle analysis, which focuses on the trajectory of individual tracers is ideal for homogeneous materials that do not interact with the particles. By contrast, the characterization of heterogeneous, micro-structured materials or those where particles interact directly with the medium requires a two-particle analysis that characterizes correlations between the trajectories of distinct particle pairs.
View Article and Find Full Text PDFInt J Antimicrob Agents
January 2025
Department of Precision Medicine, University of Campania "Luigi Vanvitelli"; Unit of Internal Medicine and Transplants, AORN Ospedali dei Colli, Ospedale V. Monaldi, Piazzale Ettore Ruggieri, 80131, Napoli, Italy. Electronic address:
Ceftobiprole, an advanced-generation cephalosporin with broad bactericidal activity, is approved for community-acquired and hospital-acquired pneumonia (excluding ventilator-associated pneumonia). We aimed to evaluate, in a real-world setting, the safety profile of ceftobiprole in patients with risk conditions (severe renal impairment, hepatic impairment, and immunocompromised status), groups excluded from clinical trials. In this retrospective study (NCT04170309), 396 consecutive charts of patients treated with ceftobiprole during 2016-2022 in 15 centers in France, Italy, and Spain were analyzed: 62 had severe renal impairment, 51 had hepatic impairment, 120 were immunocompromised, and 203 had no predefined risk condition (controls).
View Article and Find Full Text PDFImmunobiology
January 2025
Department of Pediatrics, Chinese and Western Medicine Hospital of Panzhihua, Panzhihua 617099, China.
Severe community-acquired pneumonia (SCAP) significantly threats the safety of children's lives. Long non-coding RNA (lncRNA) MANCR is overexpressed in lung adenocarcinoma (LUAD) tissue, promote the proliferation, invasion, and migration, decreased cell apoptosis of LUAD cells. This study aimed to detect lncRNA MANCR levels in pediatric SCAP, and explore the diagnostic and prognostic significance of MANCR in pediatric SCAP.
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