The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2-azirines by an iodosobenzene (PhIO)-mediated intramolecular azirination in a one-pot process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009194 | PMC |
| http://dx.doi.org/10.3762/bjoc.14.123 | DOI Listing |
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