Chagas disease, a potentially life-threatening disease caused by the protozoan parasite Trypanosoma cruzi, has become a concern in the United States as a result of human emigration from Latin America where Chagas disease is endemic (1). It is estimated that as many as 8 million people living in Mexico, and Central and South America have Chagas disease.* Most cases of Chagas disease in the United States are chronic infections; however, rare cases of acute congenital infections and autochthonous vectorborne transmission have been reported (2). To understand how data are collected and used, a review of state-level public health surveillance for Chagas disease was conducted through semistructured interviews with health officials in six states (Arizona, Arkansas, Louisiana, Mississippi Tennessee, and Texas) where Chagas disease is reportable and one (Massachusetts) where it was previously reportable. States implemented surveillance in response to blood donor screening for Chagas disease and to identify the route of disease transmission. Many states reported primarily chronic cases and had limited ability to respond to local transmission because acute cases were infrequently reported. Surveillance remains important in states with large populations of immigrants or frequent travelers from countries with endemic disease and for states with a risk for local transmission. Surveillance efforts can also help increase awareness among providers and assist in linking patients with Chagas disease to treatment to help prevent cardiac and gastrointestinal complications.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048980 | PMC |
http://dx.doi.org/10.15585/mmwr.mm6726a2 | DOI Listing |
Appl Microbiol Biotechnol
December 2024
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Malaria, a parasitic disease caused by Plasmodium spp. and transmitted by Anopheles mosquitoes, remains a major global health issue, with an estimated 249 million cases and 608,000 deaths in 2022. Rapid and accurate diagnosis and treatment are crucial for malaria control and elimination.
View Article and Find Full Text PDFAm J Trop Med Hyg
December 2024
Centro para el Desarrollo de la Investigación Científica, Asunción, Paraguay.
Most triatomine bugs inhabit nests and shelters of vertebrates, some of which are closely associated with palm trees. A few species occupy domestic and peridomestic habitats, posing a threat to human health as natural transmitters of Chagas disease. A peridomestic specimen that yielded positive results for Trypanosoma cruzi in both microscope and polymerase chain reaction tests was collected during a vector control survey in northeastern Paraguay.
View Article and Find Full Text PDFHeliyon
December 2024
Microbiology Department, Clinical Laboratory North Metropolitan Area, Germans Trias I Pujol University Hospital, 08916 Badalona, Spain.
Background And Objective: Serological screening for Chagas disease (CD) in Latin American adults living in Europe is a cost-effective strategy for transmission prevention. The World Health Organization recommends two different serological tests including native and recombinant antigens for IgG detection. In Spain, most commercialized native tests require manual processing.
View Article and Find Full Text PDFJ Med Entomol
December 2024
Laboratorio de Entomología Médica, Departamento de Ciencias de la Naturaleza, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzmán, Jalisco, México.
Chagas disease is one of the most important vector-borne diseases in Mexico. Triatoma pallidipennis (Stål) is one of the most epidemiologically important vector species. Despite being classified as a single species, various studies (molecular, morphometric, and biological) on populations across its distribution suggested it is composed of a group of cryptic species.
View Article and Find Full Text PDFCell Biol Int
December 2024
Cellular and Molecular Oncobiology Program, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
The high plasticity of cells undergoing epithelial-mesenchymal transition (EMT) promotes increased tumor heterogeneity, and its interaction with tumor-associated stromal cells appears to contribute to developing a stemness phenotype. Cells with these characteristics exhibit increased resistance to chemotherapy and radiotherapy, leading to disease relapse and metastasis. Here, we discuss the activation of the Wnt/β-catenin pathway in promoting EMT and stemness within the context of cellular resistance to these therapies.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!