In experimental heavy closed brain injury (mortality infive days - 86%) it is shown that from the first hours the violations of carbohydrate metabolism in the form of triad were formed: the marked hyperglycemia (3.3-3.6 times), hyperinsulinemia (2.4-3.2 times) and insulin resistance (HOMA-indexes increased to 8.0-11.7 times). These changes were caused by a decrease in tissue sensitivity to insulin and were accompanied by decrease in functional activity of the pancreatic β-cells. In total it is possible to consider these changes as a pentad of the typical disorders of carbohydrate metabolism at brain injury.
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| http://dx.doi.org/10.15407/fz62.04.018 | DOI Listing |
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