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Dynamic ultrasound-based modeling predictive of response to neoadjuvant chemotherapy in patients with early breast cancer.
Sci Rep
December 2024
Department of Breast Surgery, Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian, China.
Early prediction of patient responses to neoadjuvant chemotherapy (NACT) is essential for the precision treatment of early breast cancer (EBC). Therefore, this study aims to noninvasively and early predict pathological complete response (pCR). We used dynamic ultrasound (US) imaging changes acquired during NACT, along with clinicopathological features, to create a nomogram and construct a machine learning model.
View Article and Find Full Text PDFPrevalence and outcomes of nonmass lesions detected on screening breast ultrasound based on ultrasound features.
J Ultrasound
December 2024
Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Republic of Korea.
Purpose: To determine how often non-mass lesions are seen in screening breast ultrasounds, and analyze their ultrasound features according to the ultrasound lexicon to find features suggestive of malignant non-mass lesions.
Methods: This study is a single center retrospective study for nonmass lesions on screening breast ultrasound. Among 21,604 patients who underwent screening breast US, there were 279 patients with nonmass lesions.
Ultrasound-based ADNEX model for differentiating between benign, borderline, and malignant epithelial ovarian tumours.
Clin Radiol
November 2024
Department of Ultrasound, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, Fujian Province, China. Electronic address:
Background: The purpose of this study was to evaluate the ability of the International Ovarian Tumor Analysis-Assessment of Different NEoplasias in the adneXa (IOTA-ADNEX) model to distinguish among benign, borderline, and malignant epithelial ovarian tumours (BeEOTs, BEOTs, and MEOTs, respectively).
Methods: The study included 813 patients with BeEOTs, BEOTs, and MEOTs who underwent ultrasound examinations and pelvic operations. Comparisons were made between the clinical information and ultrasonographic features of the three patient groups, and the histopathological diagnosis was the gold standard.
Cost-Effectiveness of a Biomarker-Based Screening Strategy for Hepatocellular Carcinoma in Patients with Cirrhosis.
Liver Cancer
December 2024
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Introduction: Given suboptimal performance of ultrasound-based surveillance for early hepatocellular carcinoma (HCC) detection in patients with cirrhosis, there is interest in alternative surveillance strategies, including blood-based biomarkers. We aimed to evaluate the cost-effectiveness of biomarker-based surveillance in patients with cirrhosis.
Methods: We constructed a decision-analytic model to compare ultrasound/alpha-fetoprotein (AFP) and biomarker-based surveillance strategies in 1,000,000 simulated patients with compensated cirrhosis.
Ultrasound-based geometric modeling of the human ovary with applications to cryopreservation.
Cryobiology
December 2024
Biothermal Technology Laboratory, Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address:
Successful cryopreservation of the whole ovary outside of the body, while a woman undergoes cancer treatments, may help preserving fertility and regaining hormone balance during recovery. One of the key challenges in whole ovary cryopreservation is adequately loading the organ with cryoprotective agents (CPAs). Another notable challenge in developing the application is the lack of geometric data needed for designing matching thermal protocols.
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