Aims: To test the significance of association between a validated index of detrusor contractility, v , the Watts Factor, and the Detrusor Contractility Parameter, t ; and to test whether t depends on outflow tract resistance as indicated by Bladder Outlet Obstruction Index (BOOI).
Methods: Thirty-seven pressure-flow traces from 20 male and 17 female patients were analyzed and forms of the Watts Factor, t and BOOI were compared with v .
Results: The Detrusor Contractility Parameter, t , is significantly associated with v for both women and men without a high degree of bladder outlet obstruction. The Watts Factor only had a significant association with v at the point of maximum flow in women.
Conclusions: The Detrusor Contractility Parameter (DCP) (t ), can be measured easily from the pressure flow curves of a urodynamic test. The Watts Factor at maximum urine flow, WF , can be readily calculated, but is only applicable to women. In both women and men without a high degree of bladder outlet obstruction, DCP is better associated with true detrusor contractility than any Watts Factor analysis.
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http://dx.doi.org/10.1002/nau.23745 | DOI Listing |
Int Neurourol J
December 2024
Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Purpose: This investigation was conducted to elucidate the effects of eugenol on bladder contractility through experimental and in silico approaches.
Methods: To assess the impact of eugenol on muscular contractility, longitudinal strips of bladder tissue, measuring 2 mm by 6 mm, were mounted in perfusion chambers connected to an isometric force transducer. Furthermore, molecular docking studies were conducted to explore the potential of eugenol to target the M3 muscarinic acetylcholine receptor (M3R) and voltage-operated calcium channels (VOCCs) in muscle cells, utilizing in silico techniques.
J Formos Med Assoc
December 2024
Department of Life Science, College of Science, National Taiwan Normal University, 162, Section 1, Heping E. Rd., Taipei, 106, Taiwan. Electronic address:
Background/purpose: The mechanism for long-term hypoxia/ischemia induced bladder underactivity is uncertain. It requires an effectively therapeutic treatment. Therefore, we determined the pathophysiologic mechanisms of long-term bilateral partial iliac arterial occlusion (BPAO)-induced bladder underactivity and explored the therapeutic potential of adipose-derived stem cells (ADSCs) and ADSC-derived microvesicles (MVs) on BPAO-induced bladder dysfunction.
View Article and Find Full Text PDFInt Neurourol J
November 2024
Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Purpose: Predicting improvements in voiding symptoms following deobstructive surgery for male lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) is challenging when detrusor contractility is impaired. This study aimed to develop an artificial intelligence model that predicts symptom improvement after holmium laser enucleation of the prostate (HoLEP), focusing on changes in maximum flow rate (MFR) and voiding efficiency (VE) 1-month postsurgery.
Methods: We reviewed 1,933 patients who underwent HoLEP at Samsung Medical Center from July 2008 to January 2024.
Rev Assoc Med Bras (1992)
November 2024
Universidade Estadual de Campinas - Campinas (SP), Brazil.
Objective: Initially diagnosed as a respiratory disease, SARS-CoV-2 revealed numerous extrapulmonary implications. The aim of this study was to investigate prolonged urinary retention in survivors post-COVID-19 infection that led to hospitalization.
Methods: A retrospective cohort analysis included male and female patients hospitalized during the COVID-19 pandemic in a reference center hospital.
Medicine (Baltimore)
November 2024
Department of Urology, Continence Research Clinic, Shaoyang Central Hospital, Shaoyang, China.
Benign prostate hyperplasia is the leading cause of lower urinary tract symptoms due to bladder outlet obstruction (BOO) in elderly male patients. The impact of prostate volume (PV) on clinical and urodynamic characteristics was evaluated in those patients with BOO requiring prostate de-obstruction maneuvers in this study. We retrospectively reviewed the clinical data of 301 patients underwent transurethral resection of prostate due to combination with urinary retention (UR) alone and bladder stone (BS) alone.
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