Acoustic computing devices, including switches, logic gates, differentiator and integrator, have attracted extensive attentions in both academic research and engineering. However, no scheme of acoustic computing device with more complex functionality has been proposed, such as ordinary differential equation (ODE) solver. Here, we propose an acoustic analog computing (AAC) system based on three cascaded metasurfaces to solve the nth-order ODEs. The metasurfaces are constructed with layered labyrinthine units featuring broad amplitude and phase modulation ranges. The simulated transmitted pressure of the AAC system agrees well with the theoretical solution of ODE, demonstrating the excellent functionality. Unlike the optical ODE solver based on differentiator or integrator, whose geometry becomes more complicated for solving higher order ODE, the proposed AAC system with fixed geometry can be designed for arbitrary nth-order ODE in principle. The proposal may find applications in various scenarios such as acoustic communication, analog computing and signal processing.
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http://dx.doi.org/10.1038/s41598-018-27741-2 | DOI Listing |
Epigenetics
December 2025
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
RNA N6-methyladenosine (m6A) plays diverse roles in RNA metabolism and its deregulation contributes to tumor initiation and progression. Clear cell renal cell carcinoma (ccRCC) is characterized by near ubiquitous loss of followed by mutations in epigenetic regulators , , and . Mutations in , a histone H3 lysine 36 trimethylase (H3K36me3), are associated with reduced survival, greater metastatic propensity, and metabolic reprogramming.
View Article and Find Full Text PDFMol Divers
January 2025
Department of Biophysics, Panjab University, Chandigarh, 160014, India.
Alzheimer's disease (AD) is a degenerative neurological disorder defined by the formation of β-amyloid (Aβ) plaques and neurofibrillary tangles within the brain. Current pharmacological treatments for AD only provide symptomatic relief, and there is a lack of definitive disease-modifying therapies. Chemical chaperones, such as 4-Phenylbutyric acid (4PBA) and Tauroursodeoxycholic acid, have shown neuroprotective effects in animal and cell culture models.
View Article and Find Full Text PDFNanoscale
January 2025
Chemical and Biomolecular Engineering, University of Nebraska - Lincoln, Lincoln, Nebraska, 68588, USA.
The synergistic optical, electronic, and chemical properties of metal nanoparticles present in close proximity have potential applications in energy, medicine, and sustainability. Fundamental studies and application development based on spontaneous self-assembly of one-dimensional (1D) chains of metal nanoparticles without external organization agencies have been pursued for over four decades. The spontaneous formation of 1D chains in a solution of stabilized spherical nanoparticles may be driven by the emergence of local anisotropy due to dipolar interaction, representing a trapped non-equilibrium state.
View Article and Find Full Text PDFMethods Enzymol
January 2025
Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv, Israel. Electronic address:
A-to-I RNA editing is an RNA modification that alters the RNA sequence relative to the its genomic blueprint. It is catalyzed by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes, and contributes to the complexity and diversification of the proteome. Advancement in the study of A-to-I RNA editing has been facilitated by computational approaches for accurate mapping and quantification of A-to-I RNA editing based on sequencing data.
View Article and Find Full Text PDFInt J Sports Physiol Perform
January 2025
Laboratory of the Metabolic Adaptations to Exercise Under Physiological and Pathological Conditions (AME2P) UPR 3533, CRNH Auvergne, Clermont Auvergne University, Clermont-Ferrand, France.
Purpose: The impact of weight cycling (WC)-successive weight loss (WL) and weight regain (WG)-on athlete performance is well documented, but effects on appetite are not. This study assessed the impact of a WC episode on dietary and appetitive profiles in athletes, considering sex and sport type.
Methods: Athletes (28 male, 20 female) from combat (n = 23), strength (n = 12), and endurance (n = 13) sports participated in 3 conditions during a WC episode (baseline, WL, WG).
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