AI Article Synopsis
- RAGE is a receptor linked to inflammation and oxidative stress, with various ligands including AGEs and HMGB-1.
- Recent studies highlight how metals like methylmercury and arsenic can influence RAGE expression, leading to behavioral changes based on exposure methods and age.
- A new model has been proposed to further investigate RAGE-related issues, especially in relation to metal exposure and its health impacts.
Article Abstract
The receptor for advanced glycation end products (RAGE), a multi-ligand receptor, is mostly associated with promoting inflammation and oxidative stress. In addition to advanced glycation end products (AGEs), its ligands include High mobility group box 1 protein (HMGB-1), S-100 proteins and beta-sheet fibrils. The effects of several metals and metalloids on RAGE expression and activation have been recently studied: in vivo and in vitro exposure to methylmercury, selenium, zinc, manganese, and arsenic was associated with a variety of RAGE-related alterations and behavioral impairments, which are mostly dependent upon the administration procedure (local vs. systemic) and age during exposure. Recently, has been proposed as a potential novel model for studying RAGE-related pathologies; preliminary data regarding such model and its potential contribution to the study of metal-induced RAGE-related pathologies are discussed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069300 | PMC |
| http://dx.doi.org/10.3390/ijerph15071407 | DOI Listing |
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