Amphiphilic Janus particles demonstrate unique assembly structures when dried on a hydrophilic substrate. Particle orientations are influenced by amphiphilicity and Janus balance. A three-stage model is developed to describe the process. Simulation further indicates the dominant force is capillary attraction due to the interface pinning at rough Janus boundaries.
Four-component lipid nanoparticles (LNPs) and viral vectors are key for mRNA vaccine and therapeutics delivery. LNPs contain ionizable lipids, phospholipids, cholesterol, and polyethylene glycol (PEG)-conjugated lipids and deliver mRNA for COVID-19 vaccines to liver when injected intravenously or intramuscularly. In 2021, we elaborated one-component ionizable amphiphilic Janus dendrimers (IAJDs) accessing targeted delivery of mRNA.
Amphiphilic dendrons or Janus dendrimers self-assembling into nanoscale vesicles offer promising avenues for drug delivery. Triazine-carbosilane dendrons have shown great potential for the intracellular delivery of rose bengal, additionally enhancing its phototoxic activity through non-covalent interactions. Thus, understanding the complexation dynamics between dendrons and photosensitizers is crucial for the development of efficient drug carriers.
Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China.
Imaging-guided chemo-photothermal combination therapy (chemo-PTT) is recognized for its synergistic therapeutic effects, reduced side effects, and minimal drug resistance, while the development of such theranostics has been hampered by poor imaging and therapy performance and tedious formulation. Herein, we introduce an all-in-one "add-on" module () for the convenient construction of doxorubicin (DOX)-loaded nanoparticles (DOX@BBT) and efficient second near-infrared (NIR-II) fluorescence imaging (FLI)-guided synergistic chemo-PTT of drug-resistant lung cancer. The delicate Janus amphiphilic structure of enables multifunctionality, including NIR-II FLI, aggregation-induced emission (AIE) characteristics, moderate photothermal conversion efficiency (PCE), excellent photostability, and polyethylene glycolation (PEGylation), which could improve the NIR-II FLI and PTT performance, relieve the complexity in theranostics, and enable high reproducibility of the multifunctional theranostics.
School of Pharmacy, Shandong Engineering Research Center of New-Type Drug Loading & Releasing Technology and Preparation, Binzhou Medical University, Yantai, Shandong, People's Republic of China.
Introduction: -induced pneumonia is marked by considerable infiltration of inflammatory cells and biofilm formation, which causes acute and transient lung inflammation and infection. Nevertheless, the discovery of alternative preventative and therapeutic methods is essential due to the high mortality rates in clinical settings and the resistance of infection to multiple medications.
Purpose: In this research, we constructed amphiphilic Janus nanoparticles (JNPs, denoted as SSK1@PDA/CaP@CIP), loaded with hydrophobic SSK1, a β-galactosidase (β-gal)-activated prodrug for reducing macrophages, and hydrophilic ciprofloxacin (CIP), a classic antibiotic for treating infection.
The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200438, P. R China.
Amphiphilic magnetic-responsive mixed-shell nanoparticles (Mag-MSNPs) with tailorable compositions are synthesized by electrostatic-mediated cross-linking of core-forming blocks of two diblock copolymers, followed by in situ growth of magnetite in the cross-linked core. The Mag-MSNPs have a magnetic-responsive core and hydrophilic/lipophilic mixed shells, firmly anchoring at the oil-water interface of emulsified oil droplets due to their high interfacial activity (13.1 mN m at a rather low emulsifier concentration of 1.
