The original version of this article unfortunately contained a mistake in co-author name and his affiliation. The author name should be Anthony Russo instead it was published as Antony Russo and his affiliation has been corrected.
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http://dx.doi.org/10.1007/s10597-018-0299-8 | DOI Listing |
Neurogastroenterol Motil
January 2025
Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA.
Background: Refluxate volume and pH drop following gastroesophageal reflux are mostly cleared by peristalsis. We evaluated the roles of primary volume clearing peristaltic wave (VCPW), secondary VCPW, post-reflux swallow-induced peristaltic wave (PSPW), and late primary peristaltic wave (LPPW) in refluxate clearance.
Methods: We retrospectively analyzed pH-impedance studies performed off therapy in 40 patients with typical esophageal symptoms.
Alzheimers Dement
December 2024
Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Background: Alzheimer's disease (AD) and related dementias can have long preclinical phases; thus, midlife intervention and prevention methods could prove efficacious. Multiple health-related lifestyle factors have been associated with risk for AD. However, research on lifestyle factors has focused on clinical outcomes such as cognitive decline, mild cognitive impairment and/or AD dementia; their associations with potential early changes in cerebrospinal fluid (CSF) biomarkers are less understood.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Parkville, VIC, Australia.
Background: PET quantification using the Standardised Uptake Value Ratio (SUVR) relies on the availability of a robust reference region. Intrinsic noise, spill in, and specific binding in the reference region can impact the reliability of the resulting SUVR. We evaluate a novel deep learning method trained on longitudinal data that penalises unexpected temporal changes and learns a SUVR correction factor that compensates for any noise or bias in the reference region, resulting in an improved quantification.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Geriatric Research Education and Clinical Center William S. Middleton VA Hospital, Madison, WI, USA.
Background: Obstructive sleep apnea (OSA) is associated with hypoxia-induced neuronal impairment and dysfunction-key risk factors for the pathogeneses of age-related neurodegenerative diseases such as Alzheimer's disease (AD). This study examined longitudinal associations between OSA severity and CSF biomarkers associated with AD, synaptic dysfunction, and neuroinflammation in a sample of late-middle-aged adults with increased risk for AD.
Method: N=25 cognitively unimpaired adults (64% female, mean age 65.
Alzheimers Dement
December 2024
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Background: Synaptic loss is a key feature of Alzheimer's disease (AD) dementia. In the entorhinal cortex (ERC) and hippocampus, phosphorylated tau (pTau) colocalizes with synaptosomes, and its presence may play a role in AD-related synaptic loss. However, the relationship between pTau and synaptic density is not well understood.
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