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Effects and Impact of Selenium on Human Health, A Review.
Molecules
December 2024
School of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550003, China.
Article Synopsis
- Selenium is an essential trace element that plays a vital role in human health through its incorporation in selenoproteins, which perform various biological functions, including antioxidant activity and immune system enhancement.
- More than 30 selenoproteins have been identified, with key examples like glutathione peroxidases (GPXs) and thioredoxin reductases (TrxRs) being studied for their health benefits.
- Due to the narrow margin between adequate and toxic doses of selenium, it's crucial to regulate intake levels to prevent deficiencies and toxicity, highlighting its importance in nutritional guidelines and public health.
Toxicity of nickel, copper, and selenium in medaka embryos (oryzias latipes): a comparative study.
J Toxicol Sci
January 2025
Department of Creative engineering, National Institute of Technology, Ariake College.
Article Synopsis
- The study emphasizes the significance of nickel, copper, and selenium as essential biometals in various industries, but highlights their harmful impact as environmental pollutants when they exceed normal levels, particularly in aquatic ecosystems.
- Research on medaka fish embryos revealed that exposure to these biometals led to significant developmental abnormalities and increased mortality rates throughout a 14-day observation period.
- Gene expression analysis showed that copper was the most toxic, affecting over 4,700 genes, while all three biometals caused detrimental effects on fish embryo development, underscoring the necessity of monitoring biometal levels to protect aquatic life.
Disentangling the role of selenium in antagonizing the toxicity of arsenic and cadmium.
Arch Toxicol
January 2025
Department of Biomedicine and Environmental Research, Faculty of Medicine, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, Konstantynów Ave. 1J, 20-708, Lublin, Poland.
Cadmium (Cd) and inorganic arsenic (As) compounds are considered to be among the major public health hazards. This is due to both the high intrinsic toxicity of these substances and the often difficult to avoid exposure of the general population through contaminated water and food. One proposed method to reduce the toxic effects of As and Cd on animals and humans is the use of selenium (Se).
View Article and Find Full Text PDFEvaluation of antidiabetic and anti-inflammatory action of selenium nanoparticles mediated through aspalathus linearis - An in vitro study.
Med J Malaysia
January 2025
Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, India.
Introduction: Selenium nanoparticles (SeNPs) have drawn a lot of interest among researchers because of their distinct impact on antioxidant activity, anti-inflammatory tests, antibacterial activity, and in the treatment of various diseases. A. linearis has shown great findings in biomedical applications because of its physio-chemical compounds such as Aspalathin, orientin, and isoorientin.
View Article and Find Full Text PDFThe ameliorative effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced ovarian toxicity in female albino rats.
J Ovarian Res
January 2025
Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Background: Recently, silver nanoparticles (Ag-NPs) were shown to provoke oxidative stress through the release of reactive oxygen species and consequently induce cell damage. Selenium-loaded chitosan nanoparticles (CS-SeNPs) have anti-inflammatory and antioxidant effects, indicating that they ameliorate Ag-NPs-induced ovarian toxicity.
Objective: This study aimed to assess how well CS-SeNPs counteract the damaging effects of Ag-NPs on the ovarian tissue of adult female albino rats.
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