The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018412 | PMC |
| http://dx.doi.org/10.3389/fphys.2018.00646 | DOI Listing |
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