What happens to memories as days, weeks and years go by has long been a fundamental question in neuroscience and psychology. For decades, researchers have attempted to identify the brain regions in which memory is formed and to follow its changes across time. The theory of systems consolidation of memory (SCM) suggests that changes in circuitry and brain networks are required for the maintenance of a memory with time. Various mechanisms by which such changes may take place have been hypothesized. Recently, several studies have provided insight into the brain networks driving SCM through the characterization of memory engram cells, their biochemical and physiological changes and the circuits in which they operate. In this Review, we place these findings in the context of the field and describe how they have led to a revamped understanding of SCM in the brain.
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Neuronal theta oscillation of hippocampal ensemble and memory function.
Behav Brain Res
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Department of Neurology, Changzhi People's Hospital, Changzhi, 046000, Shanxi Province, China. Electronic address:
Memory is the ability to acquire and store information following an experience, which can be retrieved by related context exposure. Pioneering studies have demonstrated that sparsely distributed neuronal ensembles or engram cells can serve as neural substrates for storing and recalling memory traces. Many studies of neuronal ensembles have focused on the hippocampus, and increasing evidence has indicated that the neuronal oscillation is closely associated with hippocampal memory functions, including both encoding and retrieval processes.
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