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The epigenetic mechanisms of adaption to the hot and humid climate in Hu sheep (Ovis aries).
Physiol Rep
December 2024
Chongqing Academy of Animal Sciences, Chongqing, China.
Hu sheep is characterized by its excellent fecundity and high adaptability to various ecological environments. To reveal the molecular basis involved in Hu sheep, we first examined the 10 index of neuroendocrine and metabolism in blood in Hu sheep during non-stress period (April-May) and stress period (July-August) using ELISA, including CRH, adrenocorticotropic hormone (ACTH), cortisol, aldosterone, adrenaline, T3,T4, SOD, GSH-PX, and T-AOC. Then we conducted the Whole genome DNA methylation sequencing in blood and performed the comparative analysis of global DNA methylation between the non-stress period and the stress period.
View Article and Find Full Text PDFThe diagnostic yield of inferior petrosal sinus sampling in Cushing syndrome in the era of ovine CRH shortage.
Acta Neurochir (Wien)
April 2024
Department of Endocrinology, Diabetology and Metabolism, University Hospital of Basel, Basel, Switzerland.
Purpose: The ovine corticotropin-releasing hormone (oCRH) stimulation test has been routinely used in the diagnostic work-up of ACTH-dependent Cushing syndrome (CS). With oCRH currently being out-of-stock in Europe, we aimed at evaluating the diagnostic performance of inferior petrosal sinus sampling (IPSS) without oCRH stimulation.
Methods: We compared the values of 40 patients with ACTH-dependent CS and negative MRI findings in whom ACTH was measured before and after oCRH stimulation.
Prenatal cortisol exposure impairs adrenal function but not glucose metabolism in adult sheep.
J Endocrinol
March 2024
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK.
Article Synopsis
- This study examines how increased fetal cortisol levels, common in adverse prenatal conditions, affects adult sheep's metabolism and hormonal responses, particularly focusing on glucose-insulin dynamics and pituitary-adrenal function.
- Results indicated that while birth weight remained unchanged, lambs whose mothers received cortisol during late gestation had higher body weight after birth, but their glucose and insulin sensitivity were unaffected by prenatal cortisol levels.
- However, prenatal cortisol exposure led to reduced adrenal responsiveness in adulthood, notably lower cortisol responses to insulin-induced hypoglycemia and higher concentrations of ACTH, suggesting that prenatal cortisol can alter stress response mechanisms later in life.
RNA-Seq reveals ACTH-induced steroid hormone pathway participating in goat adrenal gland response to castration.
Sci Rep
August 2023
Laboratory of Sheep and Goat Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.
Article Synopsis
- The study looked at how removing the testicles (castration) affects hormone levels in goats and what happens to their adrenal glands.
- They divided 15 goats into three groups: one that got a special injection, one that had surgery, and a control group.
- After castration, the goats showed increased adrenal gland activity and changes in important hormones like ACTH and DHEA, which help produce steroids in the body.
The Role of Corticotropin-Releasing Factor (CRF) and CRF-Related Peptides in the Social Behavior of Rodents.
Biomedicines
August 2023
Department of Pathophysiology, Albert Szent-Györgyi School of Medicine, University of Szeged, 6720 Szeged, Hungary.
Since the corticotropin-releasing factor (CRF) was isolated from an ovine brain, a growing family of CRF-related peptides has been discovered. Today, the mammalian CRF system consists of four ligands (CRF, urocortin 1 (Ucn1), urocortin 2 (Ucn2), and urocortin 3 (Ucn3)); two receptors (CRF receptor type 1 (CRF1) and CRF receptor type 2 (CRF2)); and a CRF-binding protein (CRF-BP). Besides the regulation of the neuroendocrine, autonomic, and behavioral responses to stress, CRF and CRF-related peptides are also involved in different aspects of social behavior.
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