AI Article Synopsis
- The study explored the relationship between central obesity and sexual maturation in Korean girls with precocious puberty, analyzing data from 72 girls under 8 years old.
- Increased visceral fat thickness (VFT) was linked to an earlier onset of breast development, but VFT levels were not significantly different between girls with central precocious puberty (CPP) and those without.
- Overweight CPP girls displayed higher insulin resistance compared to their normal-weight peers, while insulin resistance levels did not vary in non-CPP girls based on weight.
Article Abstract
Purpose: This study aimed to investigate associations of central obesity with sexual maturation and metabolic parameters in Korean girls with precocious puberty.
Methods: This retrospective study evaluated data from 72 girls under 8 years of age with a chief complaint of early breast development. The patients were categorized as central precocious puberty (CPP) subjects or non-CPP subjects based on their gonadotropin-releasing hormone stimulation test results. Visceral fat thickness (VFT) was measured using ultrasonography and defined as the distance from the linea alba to the aorta. Patient anthropometric, metabolic, and hormonal parameters were also evaluated.
Results: Increased VFT was correlated with an earlier onset of thelarche among all study subjects (r=-0.307, P=0.034). Overweight CPP subjects showed higher insulin resistance than normal weight CPP subjects. Insulin resistance was not significantly different between overweight and normal weight non-CPP subjects. VFT was not significantly different between CPP and non-CPP subjects (2.22±0.79 cm vs. 2.74±1.47 cm, P=0.169). However, overweight and obese CPP subjects (body mass index percentile>85%) had lower VFT than non-CPP obese subjects.
Conclusion: Central obesity, defined using ultrasonography-measured VFT, might be associated with early pubertal development in Korean girls. However, VFT was not higher in CPP than non-CPP patients and was not significantly correlated with insulin resistance. Further longitudinal studies with a larger cohort are needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057024 | PMC |
| http://dx.doi.org/10.6065/apem.2018.23.2.81 | DOI Listing |
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