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| http://dx.doi.org/10.1016/j.jgar.2018.06.015 | DOI Listing |
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Multidrug-resistant urethritis caused by : susceptibility pattern and fosfomycin as an alternative treatment.
Sex Transm Infect
January 2025
Department of Clinical Microbiology, Biomedical Diagnostic Center (CDB), Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain.
National Multicenter Study on the Prevalence of Carbapenemase-Producing Enterobacteriaceae in the Post-COVID-19 Era in Argentina: The RECAPT-AR Study.
Antibiotics (Basel)
November 2024
Servicio Antimicrobianos, National Reference Laboratory in Antimicrobial Resistant, National Institute of Infectious Diseases (INEI), Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) "Dr. Carlos G Malbrán", Ave. Velez Sarsfield 563, Buenos Aires City 1281, Argentina.
Unlabelled: The COVID-19 pandemic has exacerbated the global antimicrobial resistance (AMR) crisis. Consequently, it is more urgent than ever to prioritize AMR containment and support countries in improving the detection, characterization, and rapid response to emerging AMR threats. We conducted a prospective, multicenter study to assess the prevalence of carbapenemase-producing Enterobacterales in infectious processes in Argentina during the post-COVID-19 pandemic period and explore therapeutic alternatives for their treatment (RECAPT-AR study).
View Article and Find Full Text PDFAntibiotic efficacy and resistance patterns of urinary tract infection-causing bacteria in dogs and resistome of multidrug-resistant via whole genome sequencing in South Korea.
Front Vet Sci
November 2024
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Bacterial urinary tract infections (UTIs) are prevalent in dogs and necessitate antibiotic intervention. However, the emergence of multidrug-resistant (MDR) bacteria poses significant challenges to antibiotic therapy. Although fosfomycin has been demonstrated to achieve and maintain high concentrations in urine, suggesting its potential for treating UTIs in dogs, its efficacy and the resistance profiles of urinary pathogens from canine UTIs remain elusive.
View Article and Find Full Text PDFAntioxidant and Pro-Oxidant Properties of Selected Clinically Applied Antibiotics: Therapeutic Insights.
Pharmaceuticals (Basel)
September 2024
Centre of Experimental Medicine SAS, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia.
Background: The balance between antioxidants and pro-oxidants plays a significant role in the context of oxidative stress, influenced by both physiological and non-physiological factors.
Objectives: In this study, 18 prescribed antibiotics (including doxycycline hydrochloride, tigecycline, rifampicin, tebipenem, cefuroxime, cefixime, potassium clavulanate, colistin, ampicillin, amoxicillin, amikacin, nalidixic acid, azithromycin, pipemidic acid trihydrate, pivmecillinam, aztreonam, fosfomycin sodium, and ciprofloxacin) were subjected to simultaneous determination of antioxidant and pro-oxidant potential to assess if pro-oxidant activity is a dominant co-mechanism of antibacterial activity or if any antibiotic exhibits a balanced effect.
Methods: This study presents a recently developed approach for the simultaneous assessment of antioxidant and pro-oxidant potential on a single microplate in situ, applied to prescribed antibiotics.
The Impact of Fosfomycin on Gram Negative Infections: A Comprehensive Review.
Indian J Microbiol
September 2024
Autonomous State Medical College, Lakhimpur Kheri, Uttar Pradesh India.
Article Synopsis
- The rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) pathogens has severely limited treatment options for patients, prompting doctors to rely on older antibiotics like polymyxins and tetracyclines.
- Fosfomycin has gained attention for its effectiveness against both MDR and XDR bacteria, including gram-positive and gram-negative strains, as traditional antibiotics face increasing resistance.
- This review article evaluates fosfomycin's role in treating gram-negative infections, focusing on its mechanism, pharmacokinetics, clinical effectiveness, and resistance trends.
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