The purpose of this update is to provide recent knowledge and debates regarding the use of sugammadex in the fields of anesthesia and critical care. The review is not intended to provide a comprehensive description of sugammadex and its clinical use.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939138 | PMC |
| http://dx.doi.org/10.1515/jccm-2016-0005 | DOI Listing |
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Anesthesia for Bronchoscopy-An Update.
J Clin Med
October 2024
Department of Anesthesiology and Perioperative Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
The field of interventional pulmonology has grown immensely and is increasingly recognized as a subspecialty. The new procedures introduced in the last decade pose unique challenges, and anesthesiologists need to readapt to their specific demands. In this review, we extensively discuss the pathophysiology, technical aspects, preprocedural preparation, anesthetic management, and postprocedural challenges of many new procedures such as navigational bronchoscopy, endobronchial valve deployment, and bronchial thermoplasty.
View Article and Find Full Text PDFThe safety and efficacy of sugammadex for reversing neuromuscular blockade in younger children and infants.
Expert Opin Drug Saf
July 2024
Department of Anesthesiology, Stony Brook University Medical Center, Stony Brook, NY, USA.
Introduction: Sugammadex, a novel selective antagonist of non-depolarizing neuromuscular blocking agents, has been shown to rapidly and effectively reverse moderate and deep paralysis in adults and pediatric patients over age 2, improving patient recovery and reducing the risk of postoperative complications.
Areas Covered: Since the use of sugammadex in patients under age 2 is not widely studied, we aim to provide an overview on the drug's application and potential use in infants and neonates. There is a limited but growing body of evidence for the safe, efficacious use of sugammadex in children under age 2.
Effect of Changing Estimated Glomerular Filtration Rate Formula on Sugammadex Use and Pulmonary Complications for African American and non-African American Patients.
Anesth Analg
November 2024
Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Background: Sugammadex is associated with fewer postoperative pulmonary complications than is neostigmine reversal of neuromuscular blockade. However, the Food and Drug Administration-approved package insert states that its use is "not recommended" in severe renal impairment, separately defined as creatinine clearance <30 mL/min. Recently, the formula for estimating glomerular filtration rate (GFR) was updated to remove the race variable.
View Article and Find Full Text PDFUpdated review on the use of neuromuscular blockade during intraoperative motor-evoked potential monitoring in the modern anesthesia era.
J Anesth
February 2024
Department of Anesthesiology, Nara Medical University, Shijo 840, Kashihara, Nara, 634-8522, Japan.
Transcranial electrical stimulation motor-evoked potentials (Tc-MEP) monitoring is a common practice in neurosurgery to prevent postoperative neurological damage. However, the use of neuromuscular blocking agents (NMBAs) during Tc-MEP monitoring is a subject of controversy. In addition, the effectiveness of sugammadex, a selective reversal agent, in the context of Tc-MEP monitoring requires further investigation.
View Article and Find Full Text PDFEfficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis.
Heliyon
August 2023
Department of Anesthesiology, Changzhou No.2 People's Hospital, Changzhou, Jiangsu, China.
Objective: In response to the differences in pharmacodynamic and pharmacokinetic characteristics of neuromuscular blocking agents between children and adults and limited studies which existing meta-analyses included, this study will update the safety and efficacy of sugammadex (Sug) sodium in reversing rocuronium-induced neuromuscular blockade in children.
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