There is growing interest in young driver training that addresses age-related factors, including incompletely developed impulse control. Two studies investigated whether training of response inhibition can reduce risky simulated driving in young drivers (aged 16-24 years). Each study manipulated aspects of response inhibition training then assessed transfer of training using simulated driving measures including speeding, risky passing, and compliance with traffic controls. Study 1 (n = 65) used a Go/No-go task, Stop Signal Task and a Collision Detection Task. Designed to promote engagement, learning, and transfer, training tasks were driving-relevant and adaptive (i.e. difficulty increased as performance improved), included performance feedback, and were distributed over five days. Control participants completed matching "filler" tasks. Performance on trained tasks improved with training, but there was no significant improvement in simulated driving. Study 2 enhanced response inhibition training using Go/No-go and SST tasks, with clearer performance feedback, and 10 days of training. Control participants completed testing only, in order to avoid any possibility of training response inhibition in the filler tasks. Again performance on trained tasks improved, but there was no evidence of transfer of training to simulated driving. These findings suggest that although training of sufficient interest and duration can improve response inhibition task performance, a training schedule that is likely to be acceptable to the public does not result in improvements in simulated driving. Further research is needed to investigate whether response inhibition training can improve risky driving in the context of real-world motivations for risky driving.
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http://dx.doi.org/10.1016/j.aap.2018.06.012 | DOI Listing |
PLoS One
January 2025
School of Energy Science and Engineering, Henan Polytechnic University, Jiaozuo, Henan, China.
In order to obtain proper speed limits in expressway work zones, CarSim and TruckSim software were used to determine the critical car and truck safe speeds and then VISSIM software was used to determine the traffic capacities and their corresponding speed limits under different upstream transition area lengths and road adhesion coefficients. The results show that critical car and truck safe speeds increase exponentially while traffic capacity and its corresponding speed limit increase logarithmically with rising road adhesion coefficient under a constant upstream transition area length, and critical car and truck safe speeds increase as a power function while traffic capacity and its corresponding speed limit increase exponentially with rising upstream transition area length under a constant road adhesion coefficient. Because Road Traffic Signs and Markings- Part 4: Work Zone (RTSM, GB 5768.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Vascular calcification severely disrupts cardiovascular hemodynamics, leading to high rates of morbidity and mortality. Despite their clinical impact, the development of effective treatments remains limited, underscoring an urgent need for efficient and reliable drug screening methods. Vascular smooth muscle cells (VSMCs) are known to play a central role in driving the calcification process, undergoing an osteogenic transition in response to pathological conditions.
View Article and Find Full Text PDFDrug Metab Pharmacokinet
December 2024
Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8654, Japan.
This study explored the evolving landscape of Microphysiological Systems (MPS), with a focus on organoids and organ-on-a-chip (OoC) technologies, which are promising alternatives to animal testing in drug discovery. MPS technology offers in vitro models with high physiological relevance, simulating organ function for pharmacokinetic studies. Organoids composed of 3D cell aggregates and OoCs mimicking in vivo environments based on microfluidic platforms represent the forefront of MPS.
View Article and Find Full Text PDFBiochemistry
January 2025
Department of Chemistry, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130, United States.
Branch-point syntheses in nonribosomal peptide assembly are rare but useful strategies to generate tripodal peptides with advantageous hexadentate iron-chelating capabilities, as seen in siderophores. However, the chemical logic underlying the peptide branching by nonribosomal peptide synthetase (NRPS) often remains complex and elusive. Here, we review the common strategies for the biosynthesis of branched nonribosomal peptides (NRPs) and present our biochemical investigation on the NRPS-catalyzed assembly of fimsbactin A, a branched mixed-ligand siderophore produced by the human pathogenic strain .
View Article and Find Full Text PDFAstrobiology
January 2025
NASA Goddard Space Flight Center, Greenbelt, Maryland, USA.
Meteoritic impacts on planetary surfaces deliver a significant amount of energy that can produce prebiotic organic compounds such as cyanides, which may be a key step to the formation of biomolecules. To study the chemical processes of impact-induced organic synthesis, we simulated the physicochemical processes of hypervelocity impacts (HVI) in experiments with both high-speed C projectiles and laser ablation. In the first approach, a C beam was accelerated to collide with ammonium nitrate (NHNO) to reproduce the shock process and plume generation of meteoritic impacts on nitrogen-rich planetary surfaces.
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