Linear and nonlinear ultrasound imaging methods highlight different damage features: the linear method detects large stiffness changes, while the nonlinear technique identifies small impedance mismatches, such as microcracks or closed delaminations. Typically, nonlinear ultrasound techniques detect damage/defects in materials by measuring higher order harmonics. These harmonics can be difficult to measure due to low magnitude and signal to noise ratios (SNR): hence large excitation amplitudes are needed, which can further complicate the reliability of these methods as equipment nonlinearities can be generated. To overcome these issues, exciting at specific frequencies, known as local defect resonances (LDR), produce a much larger displacements at the damaged regions. However, estimation of LDR is time-consuming, complex and not an easily automated process. A coupled baseline-free linear and nonlinear ultrasonic imaging approach is proposed, using a Constructive Nonlinear Array Sweep excitation and an image subtraction method for identifying damage in layered materials. The signal sweep method uses a narrow band frequency excitation to increase the probability of detection of a LDR frequency. The novel imaging approach was employed using laser vibrometry measurements in various complex composite structures to assess barely visible impact damage, critical for the aircraft industry. The results showed better estimation of impact damage when compared to classical linear or nonlinear ultrasonic methods leading to improved reliability of aircraft inspections.
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http://dx.doi.org/10.1016/j.ultras.2018.05.016 | DOI Listing |
Front Biosci (Landmark Ed)
January 2025
The First College of Clinical Medical Science, China Three Gorges University, 443000 Yichang, Hubei, China.
Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven by lipid peroxidation and tightly linked to iron metabolism, is a pivotal contributor to the oxidative stress observed in MS.
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January 2025
Cardiometabolic and Endocrine Institute, North Brunswick, NJ 08902, USA.
Human skin is a physical and biochemical barrier that protects the internal body from the external environment. Throughout a person's life, the skin undergoes both intrinsic and extrinsic aging, leading to microscopic and macroscopic changes in its morphology. In addition, the repair processes slow with aging, making the older population more susceptible to skin diseases.
View Article and Find Full Text PDFViruses
January 2025
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
The betacoronavirus genus contains five of the seven human coronaviruses, making it a particularly critical area of research to prepare for future viral emergence. We utilized three human betacoronaviruses, one from each subgenus-HCoV-OC43 (embecovirus), SARS-CoV-2 (sarbecovirus), and MERS-CoV (merbecovirus)-, to study betacoronavirus interactions with the PKR-like ER kinase (PERK) pathway of the integrated stress response (ISR)/unfolded protein response (UPR). The PERK pathway becomes activated by an abundance of unfolded proteins within the endoplasmic reticulum (ER), leading to phosphorylation of eIF2α and translational attenuation.
View Article and Find Full Text PDFViruses
January 2025
Department of Biomedical & Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.
Hepatitis E Virus (HEV) is a globally widespread pathogen that causes acute hepatitis infection. Beyond hepatic pathogenesis, HEV has been proven to cause several extrahepatic manifestations, such as neurological, renal, and hematological manifestations. It was also associated with mortality in pregnant females.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Background/objectives: Leukocytes play a significant role in both acute kidney injury (AKI) and chronic kidney disease (CKD), contributing to pathogenesis and tissue damage. The process of leukocyte infiltration into the inflamed tissues is mediated by the interactions between the leukocytes and cell adhesion molecules (CAMs, i.e.
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