Dietary restriction (DR) leads to extended lifespan in many species ranging from yeasts to mammal, and it can also affect the immune system to some extent. Herein, we investigated whether DR can enhance the immunity of Bombyx mori suffering from acute pathogenic microorganism infection. The results showed that DR could accelerate the melanisation reaction, delay the early death in silkworms, meanwhile Staphylococcus aureus (SA) load was lower in the early stage of infection. Moreover, more immune-related genes were identified to be down-regulated in the DR group infected with SA compared with the ad libitum - fed (AL) group infected with SA through mRNA deep sequencing (RNAseq) and quantitation PCR. We speculate that rapid melanization may beneficial to the lower SA load and delay the time point of the early death, and the lower SA load may lead to many immune-related DEGs were down-regulated. These results may help us to understand the mechanisms by which DR affects the immune system in insects and other animals.
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| http://dx.doi.org/10.1016/j.cbpb.2018.06.002 | DOI Listing |
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