Two polyketides, stemonones A (1) and B (2) with new skeletons, were isolated from the roots of Stemona tuberosa. Their absolute structures were fully characterized by comprehensive spectroscopic analyses and comparison of experimental electronic circular dichroism (ECD) spectra with calculated ones. The plausible biosynthetic pathways for 1 and 2 were also proposed. Anti-inflammatory assay confirmed that the two compounds showed moderate inhibitory effects on β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fitote.2018.06.025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anti-inflammatory activity and underlying mechanism against sepsis-induced acute lung injury of a low-molecular-weight polysaccharide from the root of Stemona tuberosa Lour.
Int J Biol Macromol
December 2024
School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China. Electronic address:
The root of Stemona tuberosa Lour has been used to treat tuberculosis, scabies, and eczema. Polysaccharides are among its main bioactive ingredients. A low-molecular-weight (1819 Da) polysaccharide (SPS2-A) was obtained from the root of S.
View Article and Find Full Text PDFAssessing the efficacy of roots extract against third-stage larvae of and its safety profiles.
Heliyon
October 2024
Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Thailand.
Gnathostomiasis, caused by the advanced third-stage larvae of , demands novel treatment avenues. The ethanolic root extract of has been postulated to have anthelminthic properties, suggesting its potential as an alternative remedy. In this study, roots were collected, identified, and extracted with 95 % ethanol.
View Article and Find Full Text PDFSpatial metabolomics method to reveal the differences in chemical composition of raw and honey-fried Stemona tuberosa Lour. by using UPLC-Orbitrap Fusion MS and desorption electrospray ionization mass spectrometry imaging.
Phytochem Anal
January 2025
Henan University of Chinese Medicine, Zhengzhou, China.
Introduction: Stemona tuberosa Lour. (ST) is a significant traditional Chinese medicine (TCM) renowned for its antitussive and insecticidal properties. ST is commonly subjected to processing in clinical practice before being utilized as a medicinal substance.
View Article and Find Full Text PDFLC-MS/MS analysis of didehydrostemofoline from Stemona collinsiae roots extracts in rats plasma and pharmacokinetics profile after oral administration.
Fitoterapia
July 2024
Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Thailand. Electronic address:
Stemona collinsiae Craib., Stemonaceae, has been traditionally used as medicinal plants for insecticides, treatment of parasitic worms and various diseases in Southeast Asian countries. Its ethanolic root extract has been postulated for anthelminthic activities which has a potential for development for human gnathostomiasis drug.
View Article and Find Full Text PDFNew alkaloids from Stemona tuberosa and structural revision of tuberostemonols P and R.
Fitoterapia
July 2024
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:
Three Stemona alkaloids named stemotuberines A-C (1-3) with unique CN frameworks, presumably formed by elimination of the C-11-C-15 lactone ring of the stichoneurine skeleton, were isolated from the roots of Stemona tuberosa. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and computational methods. Compounds 2 and 3 showed inhibition (IC values of 37.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!