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Methotrexate injections intralesionally as a treatment for psoriatic nails proved to be effective in large-scale studies as well as individual case reports, but the process is painful and time-consuming. The objective of this study was to compare the efficacy and safety of combined fractional CO2 laser (Fr. CO2) 10,600 nm and methotrexate gel versus methotrexate 1% gel alone in treatment of nail psoriasis.

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This case report describes an 83-year-old patient with a history of non-melanoma skin cancer who presented with a violaceous, painless nodule on the neck. Dermoscopic examination and subsequent biopsy revealed a Small/Medium CD4 T-cell lymphoproliferative disorder (SMPLPD) of the skin. Although excision was initially recommended, the patient opted for treatment with CO laser ablation.

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Article Synopsis
  • Port-wine stains (PWS) are vascular birthmarks that can darken over time, and traditional treatments like laser therapy have mixed results and side effects.
  • Hematoporphyrin Monomethyl Ether-Photodynamic Therapy (HMME-PDT) is a new approach showing promising results with fewer adverse effects by specifically targeting abnormal blood vessels.
  • The review highlights the clinical effectiveness of HMME-PDT based on assessments, notes improvements in vascular lesions, and calls for further research to establish consistent treatment guidelines and long-term outcomes.
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Treatment of onychomycosis includes topical and systemic agents. However, prolonged use of oral treatment could cause adverse effects and topical antifungal agents have limited penetration. To compare the clinical efficacy and the safety of fractional CO laser combined with topical tioconazole nail solution versus Q-switched 1064 Nd: YAG laser in the treatment of fingernail onychomycosis.

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Background: Macular amyloidosis (MA) could be of cosmetic concern with a significant psychological impact for patients, and its treatment is challenging.

Aim Of The Work: To compare the efficacy and safety of combined fractional CO laser with dimethyl sulfoxide (DMSO) 50% versus fractional CO laser alone in the treatment of macular amyloidosis.

Patients And Methods: Twenty patients with macular amyloidosis were treated with monthly session of fractional CO laser only in one side of the lesion (area A), and fractional laser followed by application of DMSO 50% solution in the other side of the lesion (area B).

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