Mon1 is a guanine nucleotide exchange factor subunit that activates the Ypt7 Rab GTPase and is essential for vacuole trafficking and autophagy in eukaryotic organisms. Here, we identified and characterized the function of Mon1, an ortholog of Mon1, in a human fungal pathogen, . Mutation in resulted in hypersensitivity to thermal stress. The deletion mutant exhibited increased sensitivity to cell wall and endoplasmic reticulum stress. However, the deletion mutant showed more resistance to the antifungal agent fluconazole. studies demonstrated that compared to the wild-type strain, the deletion mutant attenuated virulence in the insect model. Moreover, the deletion mutant was avirulent in the murine inhalation model. These results demonstrate that Mon1 plays a crucial role in stress survival and pathogenicity in .
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| http://dx.doi.org/10.1080/12298093.2018.1468053 | DOI Listing |
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