The results of isolation of an Alphavirus strain from Aedes sp. mosquitoes collected in the focus of Karelian fever are presented. According to the results of serological studies, the isolated strain LEIV-9298 Karelia belongs to the antigenic complex Sindbis-Western equine encephalomyelitis. The appurtenance of the isolated agent to the Alphavirus genus has been confirmed by electron microscopic examinations. A rise of antibody titres to LEIV-9298 Karelia virus in paired sera of subjects with a history of Karelian fever allows it to be considered the causative agent of this disease.
Download full-text PDF |
Source |
---|
J Med Microbiol
March 2023
Virology Department, Animal and Plant Health Agency, Woodham Lane, Addlestone, Surrey, KT15 3NB, UK.
Sindbis virus (SINV) is the causative agent of a febrile infection commonly called Ockelbo disease, Pogosta disease or Karelian fever in northern Europe. Finland, Sweden, Russia and South Africa experience periodic SINV outbreaks. SINV is classified within the family Togaviridae and genus Alphavirus.
View Article and Find Full Text PDFPhlebovirus is an abundant and rather heterogeneous genus within the Phenuiviridae family (order Bunyavirales). The genus Phlebovirus is divided into two antigenic complexes, which also correspond to the main vector: sandflies/mosquitoes and ticks. Previously, only sandfly/mosquito-borne phleboviruses were associated with human disease, such as Rift Valley fever virus, Toscana virus, Sicilian and Naples Sandfly fever viruses and others.
View Article and Find Full Text PDFDig Liver Dis
November 2016
Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. Electronic address:
Background: During the last several decades the prevalence of coeliac disease (CD) has increased worldwide.
Aim: To compare the cumulative incidence of CD between Estonian and Finnish children and to identify the risk factors.
Materials And Methods: Children were recruited as part of the DIABIMMUNE Study.
The active replication of Karelian fever virus (KFV) in human blood vessels and the protective activity of the Russian agent reaferon were first shown. KFL was highly susceptible to interferon (IFN)-alpha. In control (uninfected) cells, reaferon caused low gene expressions of the IFN-dependent enzymes dsRNA-dependent protein kinase and 2'5'-oligoadenylate synthetase, by exerting a little effect on the activity of its family genes.
View Article and Find Full Text PDFDuodecim
September 2011
HUS/HYKS, medisiininen tulosyksikkö, infektiosairauksien klinikka, HUS.
Clinically significant endemic, arthropod-borne infectious diseases in Finland include Lyme disease, tick-borne encephalitis, tularemia and Karelian fever. The diagnosis of early borreliosis or tularemia is clinical and the treatment is initiated already before the results of eventual blood tests. The diagnosis of late stage borreliosis, tick-borne encephalitis or Karelian fever is confirmed mainly with serologic tests.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!