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Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges.
Front Endocrinol (Lausanne)
December 2024
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Diabetic nephropathy (DN), as the most serious minor vascular complication of diabetes, imposes a significant socioeconomic and medical cost around the world, and its prevention and treatment are a major challenge in the current medical community. Observational studies and randomized controlled trials have revealed protective and risk factors for some DN. However, the conclusions of these researches may be influenced by several types of confounding.
View Article and Find Full Text PDFIdentifying influential nodes in brain networks via self-supervised graph-transformer.
Comput Biol Med
December 2024
Center for Brain and Brain-Inspired Computing Research, School of Computer Science, Northwestern Polytechnical University, Xi'an, China. Electronic address:
Background: Studying influential nodes (I-nodes) in brain networks is of great significance in the field of brain imaging. Most existing studies consider brain connectivity hubs as I-nodes such as the regions of high centrality or rich-club organization. However, this approach relies heavily on prior knowledge from graph theory, which may overlook the intrinsic characteristics of the brain network, especially when its architecture is not fully understood.
View Article and Find Full Text PDFRecent progress in the development of peptide-drug conjugates (PDCs) for cancer therapy.
Eur J Med Chem
December 2024
Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address:
Peptide-drug conjugates (PDCs) are emerging therapeutic agents composed of peptides, linkers, and payloads, which possess favorable targeting capability and can deliver enough payloads to the tumor sites with minimized impact on healthy tissues. However, only a few PDCs have been approved for clinical use so far. To advance the research on PDCs, this review summarizes the approved PDCs, and PDCs in clinical and preclinical stages based on the payload types.
View Article and Find Full Text PDFEvaluation of a Miniature, Injectable, Wireless Stimulator to Treat Obstructive Sleep Apnea.
Neuromodulation
December 2024
StimAire Corporation, Tucson, AZ, USA.
Introduction: Moderate-to-severe obstructive sleep apnea (OSA) affects a large segment of the US population and is characterized by repetitive and reversible obstruction of the upper airway during sleep. Untreated OSA is associated with increased incidence of heart attack, stroke, and motor vehicle accidents due to sleepiness. Continuous positive airway pressure is often prescribed, but most patients with OSA are nonadherent.
View Article and Find Full Text PDFChallenges and Strategies in Nursing Leadership: A Qualitative Study on Leaders in Mental Health Care.
Nurs Rep
December 2024
Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.
Aim: To explore the challenges and strategies among new and experienced nursing leaders in mental healthcare; furthermore, to identify factors that support or hinder their leadership roles.
Background: Strong nursing leadership is crucial for the quality of patient care and is associated with higher job security and better patient outcomes. Understanding what factors contribute to effective leadership is essential for the development of future leaders.
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