Stroke is a main cause for long-term disability. Stroke symptoms cover various domains, e.g., motor, sensory, language, or other cognitive functions. In clinical practice and rehabilitation research, especially motor impairment attracts much attention. However, also cognitive impairments are common after stroke, effecting approximately two-thirds of stroke patients in the acute phase. Although 30% of stroke patients spontaneously recover from their cognitive impairments, large amounts of patients remain cognitively impaired. These patients have more problems reintegrating in personal and professional life. To date, cognitive rehabilitation strategies are not yet satisfactory. One promising strategy is combining non-invasive brain stimulation (NIBS) with cognitive training. In the current review, we will discuss the relevance of cognitive impairment after stroke and innovative interventional strategies to improve cognition, such as NIBS. Furthermore, we will address the potential of using cognitive training to enhance recovery in other behavioural domains, such as the motor domain.
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http://dx.doi.org/10.1016/j.neulet.2018.06.047 | DOI Listing |
Adv Sci (Weinh)
January 2025
State Key Laboratory of Fluid Power and Mechatronic Systems, Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310058, China.
Bioinspired supramolecular architectonics is attracting increasing interest due to their flexible organization and multifunctionality. However, state-of-the-art bioinspired architectonics generally take place in solvent-based circumstance, thus leading to achieving precise control over the self-assembly remains challenging. Moreover, the intrinsic difficulty of ordering the bio-organic self-assemblies into stable large-scale arrays in the liquid environment for engineering devices severely restricts their extensive applications.
View Article and Find Full Text PDFCureus
December 2024
Department of Pediatrics, Japanese Red Cross Wakayama Medical Center, Wakayama, JPN.
Acute ischemic stroke, a medical emergency caused by reduced cerebral blood flow, results in brain cell damage. While commonly associated with older individuals, strokes can also occur in young and middle-aged adults, posing significant socio-economic and health challenges due to the long-term impact of the condition. This poses significant socio-economic and health challenges because stroke is a leading cause of disability and mortality.
View Article and Find Full Text PDFFront Bioeng Biotechnol
January 2025
Biomedical Engineering Department, College of Engineering, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Introduction: Color vision deficiency (CVD), a common visual impairment, affects individuals' ability to differentiate between various colors due to malfunctioning or absent color photoreceptors in the retina. Currently available diagnostic tests require a behavioral response, rendering them unsuitable for individuals with limited physical and communication abilities, such as those with locked-in syndrome. This study introduces a novel, non-invasive method that employs brain signals, specifically Steady-State Visually Evoked Potentials (SSVEPs), along with Ishihara plates to diagnose CVD.
View Article and Find Full Text PDFFront Neurol
January 2025
Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
HIV-associated neurocognitive disorder (HAND) is a complex neurological complication resulting from human immunodeficiency virus (HIV) infection, affecting about 50% of individuals with HIV and significantly diminishing their quality of life. HAND includes a variety of cognitive, motor, and behavioral disorders, severely impacting patients' quality of life and social functioning. Although combination antiretroviral therapy (cART) has greatly improved the prognosis for HIV patients, the incidence of HAND remains high, underscoring the urgent need to better understand its pathological mechanisms and develop early diagnostic methods.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Compelling evidence has demonstrated that rehabilitation through physical exercise, a non-invasive and non-surgical intervention, enhances muscle reinnervation and motor recovery after peripheral nerve injury (PNI) by increasing muscle-derived brain-derived neurotrophic factor (BDNF) expression and triggering TrkB-dependent axonal plasticity. Adenosine has been widely acknowledged to trigger TrkB via A2A receptor (A2AR). Since motor nerve terminals co-express TrkBs and A2ARs and depolarizing conditions increase muscle release of BDNF and adenosine, we examined whether A2ARs activation could recapitulate the functional recovery benefits of intermittent exercise after a nerve crush.
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