AI Article Synopsis
- Secreted trophic factors play a crucial role in maintaining the retina's health by regulating processes related to cell survival and response to injury.
- The retinal pigmented epithelium (RPE) and Müller cells are key players in the retinal secretome and significantly contribute to retinal diseases.
- Current therapies targeting trophic factors aim to manage inflammation, promote cell survival, and control new blood vessel growth in conditions like Age-related Macular Degeneration, Diabetic Retinopathy, and Retinopathy of Prematurity.
Article Abstract
Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.
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| http://dx.doi.org/10.1016/j.biochi.2018.06.019 | DOI Listing |
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