It is well known that remifentanil, a widely used intravenous anesthesia drug, can paradoxically induce hyperalgesia. The underlying mechanisms are still not clear despite the wide investigations. The present study demonstrated that withdrawal from spinal application of remifentanil could dose-dependently induce long term potentiation (LTP) of C-fiber evoked field potentials. Remifentanil withdrawal could activate Src family kinases (SFKs) in microglia, and upregulate the expression of tumor necrosis factor alpha (TNFα) in spinal dorsal horn. Furthermore, pretreatment with either microglia inhibitor Minocycline, SFKs inhibitor PP2 or TNF αneutralization antibody could block remifentanil withdrawal induced spinal LTP, whereas supplement of recombinant rat TNFα to the spinal cord could reverse the inhibitory effect of Minocycline or PP2 on remifentanil withdrawal induced LTP. Our results suggested that TNFαrelease following SFKs activation in microglia is involved in the induction of LTP induced by remifentanil withdrawal.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11064-018-2582-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preclinical evaluation of abuse potential of the peripherally-restricted kappa opioid receptor agonist HSK21542.
Regul Toxicol Pharmacol
December 2024
Saifu Laboratories Co., Ltd., Beijing, China; SAFE Medical Technology Co., Ltd., Hebei, China. Electronic address:
Article Synopsis
- HSK21542 is a kappa opioid receptor (KOR) agonist designed for pain relief and has been assessed for its potential for abuse prior to approval.
- The preclinical studies involved various tests in rats, including self-administration, drug discrimination, conditioned place preference, and withdrawal assessments, to evaluate its reinforcing effects and dependence potential.
- Results indicated that HSK21542 showed no behavioral signs of abuse or dependence, suggesting it has a low potential for abuse in humans.
[Comparison of the effects of general anesthesia between remimazolam and propofol in pediatric patients undergoing binocular strabismus day surgery].
Zhonghua Yi Xue Za Zhi
July 2024
Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
To compare the effects of general anesthesia between remimazolam and propofol in pediatric patients undergoing binocular strabismus day surgery. Prospectively, 60 pediatric patients, American Society of Anesthesiologists (ASA) grade Ⅰ-Ⅱ, scheduled to undergo binocular strabismus daytime surgery in Beijing Tongren Hospital under general anesthesia with laryngeal mask airway from December 2021 to May 2022 were selected. They were randomly divided into Remimazolam group and Propofol group with 30 cases in each group, according to the ratio of 1∶1 by SPSS program.
View Article and Find Full Text PDFEvaluation of the clinical efficacy of ultra-fast track anesthesia for endoscopic thoracic sympathectomy of palmar hyperhidrosis.
J Cosmet Dermatol
October 2024
Department of Anesthesiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
Objective: In this study, we investigated the safety and practicability of ultra-fast track anesthesia (UFTA) for endoscopic thoracic sympathectomy (ETS).
Methods: A total of 72 patients with palmar hyperhidrosis undergoing ETS were randomly divided into three groups: the UFTA group (group I), the group undergoing single-lumen tracheal intubation with local infiltration anesthesia technique (group II), and the group undergoing single-lumen tracheal intubation with routine anesthesia (group III). Mean arterial pressure (MAP) and heart rate (HR) were recorded for all three groups at the following six time points: Before anesthetics administration (T0), the time of intubating or inserting laryngeal mask airway (T1), the time of incising skin (T2), the time of disconnecting of the right sympathetic nerve (T3), the time of disconnecting of the left sympathetic nerve (T4), the time of withdrawing the tracheal tube or laryngeal mask airway (T5), and the time of transferring the patient to a post-anesthesia care unit (PACU) (T6).
Remifentanil-induced hyperalgesia: the current state of affairs.
Curr Opin Anaesthesiol
August 2024
Department of Anesthesiology, Perioperative & Pain Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Remifentanil-induced hyperalgesia (RIH) is a part of a general opioid-induced hyperalgesia (OIH) syndrome, seemingly resulting from abrupt cessation of continuous remifentanil infusion at rates equal or exceeding 0.3 mcg/kg/min. The intricate mechanisms of its development are still not completely understood.
View Article and Find Full Text PDFSuccessful Recovery of Cardiac Function Following 20 min of a No-touch Period in a Donation After Circulatory Death: A Case Report.
Transplantation
July 2024
Cardiac Surgery Clinic, Department of Cardiac, Thoracic-Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Background: Withdrawal of life-sustaining therapy (WLST) performed in the circulatory determination of death (DCD) donors leads to cardiac arrest, challenging the utilization of the myocardium for transplantation. The rapid initiation of normothermic regional perfusion or extracorporeal membrane oxygenation after death helps to optimize organs before implantation. However, additional strategies to mitigate the effects of stress response during WLST, hypoxic/ischemic injury, and reperfusion injury are required to allow myocardium recovery.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!