Objective: The main objective is to compare the oncologic outcomes of patients with T3 laryngeal cancers who underwent total laryngectomy or organ preservation protocol (OPP) as the initial plan of management.
Materials And Methods: This is a retrospective study on 120 patients treated for T3 laryngeal and hypopharyngeal cancers. Patients with functional larynx underwent OPP and dysfunctional larynx underwent upfront laryngectomy. Median follow-up of the patients was 4.6 years.
Results: There was a significant difference in 3 year disease-free survival (DFS) between upfront laryngectomy and OPP (73.2 vs. 55.7%; P = 0.028) group but not in 3 year overall survival (73.2 vs. 68.7%, P = 0.8). The rate laryngeal preservation was 65% in CCRT and 44% in only radiotherapy group. At 3 years, the laryngectomy-free survival was 57.2% and the laryngo-esophageal dysfunction-free survival (LEDS) was 53.0%.
Conclusion: T3 laryngeal cancers treated with upfront laryngectomy have an improved DFS when compared to those treated with non-surgical modalities. Primary surgery should be offered as an option for selected patients especially when CCRT is not feasible.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00405-018-5047-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Incidence and Management of Pharyngo Cutaneous Fistula Following Total Laryngectomy - A Single Institutional 10 Years Experience.
Indian J Otolaryngol Head Neck Surg
October 2024
Department of Surgical Oncology, Centre for Oncology, Kilpauk Medical College, MCH Resident, Government Royapettah Hospital, Chennai, India.
Article Synopsis
- - Pharyngocutaneous fistula (PCF) is a frequent complication after laryngectomy, leading to extended hospital stays and delays in further treatment, with recent studies highlighting the need for better identification of at-risk patients.
- - A review of 72 patients who had laryngectomy from 2013 to 2022 found a 23% incidence of PCF, with notable risk factors being low pre-operative albumin and advanced cancer stage; particularly, salvage laryngectomy patients experienced higher rates (32%) compared to upfront cases (16%).
- - Management strategies showed that 64% of PCF cases were treated conservatively, with 80% of upfront laryngectomy cases successfully managed this way, while
Utility of bioselection with neoadjuvant chemotherapy for organ preservation in patients with T4 laryngeal cancer.
Oral Oncol
September 2024
Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA; The Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Background: Neoadjuvant chemotherapy for induction selection of definitive treatment (IS) protocols have shown excellent outcomes for organ preservation and survival in patients with T3 laryngeal squamous cell carcinoma (LSCC). We seek to evaluate survival and organ preservation outcomes in T4 LSCC patients treated with IS protocols.
Methods: Retrospective cohort of advanced T3 and T4 LSCC patients who underwent IS protocols based upon potential for preserving a functional larynx.
Tumor volumes in T3 supraglottic cancers treated with radiotherapy in the modern era: A study of the Canadian Head & Neck Collaborative Research Initiative.
Head Neck
March 2024
Department of Otolaryngology-Head and Neck Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Article Synopsis
- The study aims to assess how the size of the primary tumor in T3 N0-3M0 supraglottic cancers affects overall survival (OS) and disease-free survival (DFS) for patients treated with intensity-modulated radiotherapy (IMRT).
- This retrospective cohort analysis involved 239 patients from Canadian cancer centers, measuring tumor volume via imaging and employing survival analysis methods.
- Results indicate that larger primary tumor volume correlates with worse OS and DFS, suggesting that patients with significant tumor sizes might benefit more from surgical intervention like laryngectomy followed by radiotherapy.*
Factors Associated with Total Laryngectomy Utilization in Patients with cT4a Laryngeal Cancer.
Cancers (Basel)
November 2023
Department of Radiation Oncology, The Ohio State University Wexner Medical Center, 410 W 10th Ave., Columbus, OH 43210, USA.
Background: Despite recommendations for upfront total laryngectomy (TL), many patients with cT4a laryngeal cancer (LC) instead undergo definitive chemoradiation, which is associated with inferior survival. Sociodemographic and oncologic characteristics associated with TL utilization in this population are understudied.
Methods: This retrospective cohort study utilized hospital registry data from the National Cancer Database to analyze patients diagnosed with cT4a LC from 2004 to 2017.
Primary Surgical Management of Laryngeal Neuroendocrine Neoplasms: A Single Institution Case Series.
Ear Nose Throat J
July 2023
Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu Provincial Medical Key Discipline (Laboratory), Nanjing, China.
Laryngeal neuroendocrine neoplasms (NENs) are rare diseases. A single institution retrospective study was done of the outcome of patients with laryngeal NENs who undergo primary surgery as the first treatment modality. Retrospective analysis of medical records of patients with laryngeal NENs between 2009 and 2018.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!