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Flavin mononucleotide, a potent inhibitor of insulin-degrading enzyme: an study.
J Biomol Struct Dyn
December 2024
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Diabetes Mellitus is a metabolic disorder which has affected over 476 million people globally with projections indicating a further increase in this number. Despite the availability of treatment therapies, maintaining optimal blood glucose levels remains a critical task. During literature survey, we came across Insulin degrading enzyme (IDE) which is responsible for insulin degradation in the body and inhibition of this enzyme could increase the bioavailability of insulin in the body.
View Article and Find Full Text PDFNatural AI-based drug designing by modification of ascorbic acid and curcumin to combat buprofezin toxicity by using molecular dynamics study.
Sci Rep
November 2024
Department of Pharmacology and Toxicology College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Article Synopsis
- Buprofezin, an insecticide used in agriculture, raises concerns about its harmful effects on non-target organisms and ecosystems, highlighting the need for safer alternatives or mitigation strategies.
- The study focuses on five key receptors involved in inflammation and immune response, and utilizes AI-driven drug design methods to explore new pharmaceuticals that may counteract the effects of harmful substances.
- The research finds strong interactions between AI-derived drugs and the receptors, with promising properties for gastrointestinal absorption and adherence to drug-likeness criteria, indicating potential for therapeutic development.
Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment.
Exp Gerontol
December 2024
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address:
Aging is an invincible phenomenon that is a risk factor for the development of neurological disorders such as anxiety, depression, and memory decline that are prominent in aging. The present study aims to evaluate the effect of Niacin (Nn) on D-galactose (D-Gal)-induced behavioral deficits and memory impairment in rats. In the experiment, forty-eight male albino Sprague dwaley rats were divided on a random basis into six groups (n = 8): Veh + Veh, Veh + Nn (low dose), Veh + Nn (high dose), Veh + D-Gal, D-Gal+Nn (low dose), D-Gal+Nn (high dose).
View Article and Find Full Text PDFHybrid Molecules Containing Methotrexate, Vitamin D, and Platinum Derivatives: Synthesis, Characterization, In Vitro Cytotoxicity, In Silico ADME Docking, Molecular Docking and Dynamics.
Chem Biodivers
January 2025
Department of Chemistry, University of Fort Hare, Alice Campus, 5700, Alice, Eastern Cape, South Africa.
Designing hybrid-based drugs is one promising strategy for developing effective anticancer drugs that explore combination therapy to enhance treatment efficacy, overcome the development of drug resistance, and lower treatment duration. Bisphosphonates and Vitamin D are commonly administered drugs for the treatment of bone diseases and the prevention of bone metastases. Platinum-based and methotrexate are widely used anticancer drugs in clinics.
View Article and Find Full Text PDFNon-Covalent Interaction of Folic Acid and 5-Methyltetrahydrofolate with Caseinates Improves the Folates Stability Studied by Multi-Spectroscopic Analysis and Molecular Docking.
Foods
August 2024
Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, China.
Folates, a crucial B-group vitamin, serve as a significant functional food supplement. Nevertheless, considerable obstacles persist in improving folates stability in liquid products. In this study, folic acid (FA) and 5-methyltetrahydrofolate (MTFA), two approved sources of folates, were encapsulated with sodium caseinate (NaCas) to enhance their stability.
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