AI Article Synopsis

  • Calciphylaxis is a rare and serious condition mainly seen in patients with advanced kidney disease or those who have undergone a kidney transplant.
  • Nonuremic calciphylaxis causes tissue death due to insufficient blood flow, and is linked to various health issues such as hyperparathyroidism and certain cancers.
  • Early diagnosis and a strong teamwork approach in treatment are crucial for improving survival rates.

Article Abstract

Calciphylaxis is a rare disease that typically presents in patients with end-stage renal disease on dialysis or those who have received a renal transplant. Nonuremic calciphylaxis leads to ischemia and subsequent necrosis of subcutaneous tissue. Diseases associated with nonuremic calciphylaxis include primary hyperparathyroidism, connective tissue disease, malignancy, and alcoholic liver disease. Due to its high mortality, early identification and an aggressive multidisciplinary treatment approach is necessary to improve patient outcomes.

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Source
http://dx.doi.org/10.1097/01.JAA.0000532115.75508.72DOI Listing

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Article Synopsis
  • - Calciphylaxis is a serious condition characterized by the calcification of small blood vessels, leading to tissue damage and ulcers, often seen in individuals with end-stage renal disease but can also affect those without kidney issues.
  • - Risk factors for calciphylaxis include diabetes, hyperparathyroidism, certain cancers, use of warfarin, liver disease, and autoimmune disorders, making it essential to recognize these factors for effective diagnosis and treatment.
  • - A case study describes a 58-year-old man with end-stage renal disease who developed penile calciphylaxis, leading to rapid tissue necrosis; he chose conservative treatment over surgery, opting for local wound care and antibiotics instead.
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Calciphylaxis is a rare and devastating condition found almost exclusively in patients with end-stage renal disease. Nonuremic calciphylaxis, an even more rare diagnosis, occurs in patients with preserved kidney function. We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing.

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Calciphylaxis (CP) is a serious, potentially life-threatening disease that presents with medial calcification of small-sized vessels and painful ischemic ulcerations. Although calciphylaxis is frequently seen in patients with end-stage kidney disease on dialysis (calcific uremic arteriolopathy, CUA), there are reported cases of nonuremic calciphylaxis (NUC), which often remain undiagnosed. We conducted a retrospective chart review at our dermatological hospital and evaluated data concerning the epidemiology, comorbidities, medication, laboratory abnormalities, and therapeutic approaches of 60 patients diagnosed with calciphylaxis between 01/2012 and 12/2022.

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