Risk biomarkers enable precision in public health.

Per Med

Center for Epidemiology, Division of Population Health, Faculty of Biology, Medicine & Health, The University of Manchester, Stopford Building, 99 Oxford Rd, Manchester, M13 9PG, UK.

Published: July 2018

Precision medicine uses biomarkers to diagnose disease. However, they can also be used to measure risk of disease. Thus, biomarkers herald a new addition to public health - Precision Public Health. We examine the implications. Risk biomarkers are identified by analyzing population cohorts. They constitute risk factors in mathematical 'Disease Risk Models'. The risk may be fixed as in a genetic biomarker or variable as in some protein biomarkers. They help monitor current risk of disease in an individual, thereby aiding efforts to reduce risk. In the UK, the NHS Health Check system is a universal system for assessing risk and for risk reduction. The system can now make use of modern biomarkers once appropriate infrastructure and governance are in place.

Download full-text PDF

Source
http://dx.doi.org/10.2217/pme-2017-0068DOI Listing

Publication Analysis

Top Keywords

public health
12
risk
10
risk biomarkers
8
precision public
8
health precision
8
risk disease
8
biomarkers
5
biomarkers enable
4
enable precision
4
health
4

Similar Publications

Bisphenol A (BPA), an environmental endocrine disrupting chemical, is one of the most widely used chemicals in the world and is widely distributed in the external environment, specifically in food, water, dust, and soil. BPA exposure is associated with abnormal cognitive behaviors. However, the underlying mechanism remains unclear.

View Article and Find Full Text PDF

Mandibular trabecular bone pattern before and two years after medical or surgical obesity treatment in young Swedish women.

Clin Oral Investig

January 2025

Department of Behavioral and Community Dentistry, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, P.O. Box 450, Gothenburg, SE-40530, Sweden.

Objective: To investigate if changes in body mass index (BMI) result in changes of the mandibular trabecular bone structure.

Materials And Methods: Females (18-35 years at baseline, mean BMI 42,3) were followed from before (n = 117) until two years (n = 66) after obesity treatment (medical or surgical). The mandibular bone trabeculation was classified as sparse, dense, or mixed on intraoral radiographs (Lindh's index).

View Article and Find Full Text PDF

Serologic and Molecular Evidence of Arboviruses in Nonhuman Primates in Northeast Brazil.

Ecohealth

January 2025

Universidade Federal do Vale do São Francisco, Rodovia BR-407, KM 12, Lote 543, Sem Número, Projeto de Irrigação Nilo Coelho, Petrolina, Pernambuco, 56300-000, Brazil.

Arbovirus surveillance in marmosets (Callithrix spp.) that live close to humans helps identify viral circulation in the environment and contributes to public health. We investigated the exposure to arboviral infections in 47 captive and free-living Callithrix from urban and peri-urban areas in the semiarid region of northeastern Brazil (SNB) in 2018.

View Article and Find Full Text PDF

Background: Depression and anxiety are commonly experienced by people with chronic kidney disease (CKD). This study aimed to evaluate person- and service-level factors associated with depression and anxiety symptoms. We sought to also understand utilisation of mental health treatments and preferences for future psychological support.

View Article and Find Full Text PDF

[Anemia classification, prevalence and predictive factors in inflammatory bowel disease].

Orv Hetil

January 2025

1 Semmelweis Egyetem, Általános Orvostudományi Kar, Belgyógyászati és Onkológiai Klinika Budapest, Korányi S. u. 2/a, 1083 Magyarország.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!