Increasing scrutiny of the role and actions of emergency responders in the aftermath of mass casualty events has led to improvements and advances in terms of treatment and care. However, despite these improvements, the authors have identified a growing concern relating to the identification of incapacitated patients and those unable to provide any identifying details, such as pediatric patients. The use of visual identification and the reliance on personal effects within the vicinity of a victim, either living or deceased, has resulted in mistaken identification in a number of major international incidents. The purpose of this article is to consider whether commonly used scientific methods for identification of the deceased could and should be broadened to include victims who are incapacitated and unable to confirm their own identity. The medicolegal questions that may arise when applying identification methods established for deceased patients to the living casualty will also be examined. (Disaster Med Public Health Preparedness. 2019;13:338-344).
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http://dx.doi.org/10.1017/dmp.2018.38 | DOI Listing |
J Neurol
December 2024
Department of Neurology, Mayo Clinic in Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
Background And Objectives: The term rapid progressive dementia (RPD) may be applied to patients who develop dementia within 1 year or complete incapacitation within 2 years of the first symptom of impairment. However, in select cases, cognitive impairment may emerge abruptly, with symptoms evolving across hours or days. We sought to determine the frequency, etiologies, and factors that associated with ultra-RPD.
View Article and Find Full Text PDFbioRxiv
May 2024
Department of Pediatrics, Division of Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Dystonia is the third most common movement disorder and an incapacitating co-morbidity in a variety of neurologic conditions. Dystonia can be caused by genetic, degenerative, idiopathic, and acquired etiologies, which are hypothesized to converge on a "dystonia network" consisting of the basal ganglia, thalamus, cerebellum, and cerebral cortex. In acquired dystonia, focal lesions to subcortical areas in the network - the basal ganglia, thalamus, and cerebellum - lead to a dystonia that can be difficult to manage with canonical treatments, including deep brain stimulation (DBS).
View Article and Find Full Text PDFNeuroimage Clin
June 2024
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
J Pain
August 2024
Cumming School of Medicine, Department of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Migraine is a complex and highly incapacitating neurological disorder that affects around 15% of the general population with greater incidence in women, often at the most productive age of life. Migraine physiopathology is still not fully understood, but it involves multiple mediators and events in the trigeminovascular system and the central nervous system. The identification of calcitonin gene-related peptide as a key mediator in migraine physiopathology has led to the development of effective and highly selective antimigraine therapies.
View Article and Find Full Text PDFInt J Mol Sci
January 2024
Neurology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
Mounting evidence underscores the intricate interplay between the immune system and skeletal muscles in Duchenne muscular dystrophy (DMD), as well as during regular muscle regeneration. While immune cell infiltration into skeletal muscles stands out as a prominent feature in the disease pathophysiology, a myriad of secondary defects involving metabolic and inflammatory pathways persist, with the key players yet to be fully elucidated. Steroids, currently the sole effective therapy for delaying onset and symptom control, come with adverse side effects, limiting their widespread use.
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