Background: Spermidine administration is linked to increased survival in several animal models.
Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans.
Design: This prospective community-based cohort study included 829 participants aged 45-84 y, 49.9% of whom were male. Diet was assessed by repeated dietitian-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. During follow-up between 1995 and 2015, 341 deaths occurred.
Results: All-cause mortality (deaths per 1000 person-years) decreased across thirds of increasing spermidine intake from 40.5 (95% CI: 36.1, 44.7) to 23.7 (95% CI: 20.0, 27.0) and 15.1 (95% CI: 12.6, 17.8), corresponding to an age-, sex- and caloric intake-adjusted 20-y cumulative mortality incidence of 0.48 (95% CI: 0.45, 0.51), 0.41 (95% CI: 0.38, 0.45), and 0.38 (95% CI: 0.34, 0.41), respectively. The age-, sex- and caloric ratio-adjusted HR for all-cause death per 1-SD higher spermidine intake was 0.74 (95% CI: 0.66, 0.83; P < 0.001). Further adjustment for lifestyle factors, established predictors of mortality, and other dietary features yielded an HR of 0.76 (95% CI: 0.67, 0.86; P < 0.001). The association was consistent in subgroups, robust against unmeasured confounding, and independently validated in the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR) Study (age-, sex-, and caloric ratio-adjusted HR per 1-SD higher spermidine intake: 0.71; 95% CI: 0.53, 0.95; P = 0.019). The difference in mortality risk between the top and bottom third of spermidine intakes was similar to that associated with a 5.7-y (95% CI: 3.6, 8.1 y) younger age.
Conclusion: Our findings lend epidemiologic support to the concept that nutrition rich in spermidine is linked to increased survival in humans. This trial was registered at www.clinicaltrials.gov as NCT03378843.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ajcn/nqy102 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Associations of Dietary Polyamines with Incident Type 2 Diabetes Mellitus: A Large Prospective Cohort Study.
Nutrients
January 2025
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Objectives: This study aimed to analyze the associations between dietary polyamine intake and incident T2DM.
Methods: This prospective analysis included 168,137 participants from the UK Biobank who did not have T2DM at baseline. Dietary polyamines were calculated based on portion sizes of food items and a nutrient database.
The Association of Dietary Polyamines with Mortality and the Risk of Cardiovascular Disease: A Prospective Study in UK Biobank.
Nutrients
December 2024
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Background: Polyamines, including spermidine (SPD), spermine (SPM) and putrescine (PUT), are essential for cellular physiology and various cellular processes. This study aimed to examine the associations of dietary polyamines intake and all-cause mortality and incident cardiovascular disease (CVD).
Methods: This prospective cohort study included 184,732 participants without CVD at baseline from the UK Biobank who had completed at least one dietary questionnaire.
Ex-Foods Diets Affect the Fatty Acid Profile of the Abdominal Adipose Tissue Without Significantly Affecting the Plasma Metabolome of Postweaning Piglets.
J Anim Physiol Anim Nutr (Berl)
December 2024
Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy.
Food leftovers can be used as alternative feed ingredients for monogastric to replace human-competing feedstuffs, such as cereals, recycle a waste product, reduce the feed-food competition and keep nutrients and energy in the feed-food chain. Among food leftovers, former food products (FFPs) are no more intended for human but still suitable for animal consumption. However, the metabolic impact of FFP has never been investigated.
View Article and Find Full Text PDFDietary intake of polyamines in a Spanish adult population: Age-dependent correlation with Healthy Eating Index and Dietary Inflammatory Index scores.
Nutrition
February 2025
Farmacología, Departamento de Medicina, Universidad de Oviedo, Oviedo, Spain; Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain. Electronic address:
Objectives: A healthy and balanced diet is crucial to maintaining optimal health. Understanding the benefits of different food components is essential. The polyamine spermidine is linked to age-related disease protection, but daily intakes and whether these vary with age are unknown.
View Article and Find Full Text PDFHuman Supplementation with AM3, Spermidine, and Hesperidin Enhances Immune Function, Decreases Biological Age, and Improves Oxidative-Inflammatory State: A Randomized Controlled Trial.
Antioxidants (Basel)
November 2024
Department of Genetics, Physiology and Microbiology (Animal Physiology Unit), Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain.
The positive effect of AM3, spermidine, and hesperidin, which have antioxidant and anti-inflammatory properties, on immunity is known, but their effect on the rate of aging, known as biological age (BA), is unclear. This work aims to test if the intake of a blend of AM3 (150 mg), spermidine (0.6 mg), and hesperidin (50 mg) for 2 months could decrease BA and improve immunity, redox, and inflammatory states.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!