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Almonds are extremely rich sources of lipids and flavonoids, and their consumption is associated with several health benefits. However, there are no analytical methods available to document compliance with prescribed or self-reported chronic almond consumption. The aim was to use an analytical approach that identifies metabolic profiles associated with long-term almond consumption to ascertain compliance with prescribed consumption. A multiple reaction monitoring (MRM)-profiling strategy was designed to isolate metabolic changes in erythrocytes after 12 wk of almond consumption. MRM-profiling data acquisition and analysis involve performing separate discovery and screening steps to detect molecular features related to metabolic changes between experimental groups. Samples used for this research were erythrocytes recovered at baseline, after 12 wk of almond consumption (W12-almond group), and after 12 wk of a nut-free diet (W12-control group). For the MRM-profiling discovery step, representative samples (pools) of erythrocytes from individuals of all groups were interrogated by precursor ion and neutral loss scan experiments on the basis of previous knowledge of chemical functional groups present in the samples. The outputs of the discovery phase were methods used for the MRM-profiling screening phase to interrogate individual samples on the basis of fast-MRM measurements. In addition, we screened the literature for flavonoids identified in almond skins and included them for individual sample screening. Of the 254 values monitored, 5 ratios and combinations of specific ions with receiver operating characteristic curve AUCs >0.89 provided a sensitivity of 74.2% and a specificity of 90% for blind samples presented in the model. Eight of the 31 participants (25.8%) in the W12-almond group and 3 of the 30 (10%) participants in the W12-control group were misclassified by all 5 ratios. Ratios and combinations of specific transitions were mainly related to membrane lipids. The misclassifications observed as a result of ratio performance evaluation may indicate noncompliance as supported by the dietary intake data. The parent trial was registered at www.clinicaltrials.gov as NCT02360787.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998771 | PMC |
http://dx.doi.org/10.3945/cdn.117.001545 | DOI Listing |
Nutr Hosp
December 2024
Nursing. Oswaldo Cruz Foundation.
Background: cashew nut is an almond known for its cardiovascular benefits in adults and weight gain effects in malnourished children, as supported by research. However, its impact on overweight children remains unexplored.
Objective: to analyze the effect of consuming biscuits made with cashew nut flour on the blood glucose and serum triglyceride levels of children with overweight/obesity over four weeks.
Obes Rev
December 2024
Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, School of Health and Social Development, Faculty of Health, Deakin University, Geelong, VIC, Australia.
This overview of reviews synthesizes the effectiveness of obesity prevention interventions in children and adults on BMI/zBMI, following JBI and Cochrane Handbook guidelines. The protocol was prospectively registered in OSF in September 2020. Searches for eligible reviews were run in five databases and gray literature in May 2022.
View Article and Find Full Text PDFBrain Res
December 2024
Program of Food Science and Technology, Federal University of Paraíba, João Pessoa, PB, Brazil; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Campina Grande, Cuité, CG, Brazil.
Maternal diet plays a crucial role in offspring development, directly affecting neural development and gut microbiota composition. This study aimed to assess if baru almond and oil (Dipteryx alata Vog.) could modulate intestinal microbiota, brain fatty acid profile, and enhance memory in offspring of rats treated during early life stages.
View Article and Find Full Text PDFNutr Metab Cardiovasc Dis
October 2024
Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Alimentació, Nutrició, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain.
Aims: Nuts are nutrient-dense foods touted for their health-promoting effects, especially regarding cardiovascular health, yet inconsistencies in the literature remain in relation to their effect on blood lipids. Hence, a systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of nut intake on blood lipids.
Data Synthesis: MEDLINE-PubMed and Cochrane databases were searched.
Front Nutr
November 2024
Nursing Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Background: Coronary heart disease (CHD) is a prevalent cardiovascular condition, with its incidence and mortality rates steadily rising over time, posing a significant threat to human health. Studies have indicated that polyphenols exhibit a certain degree of protective effect against coronary heart disease. However, the findings regarding the impact of polyphenol-rich seed foods on patients with CHD have yielded inconsistent results.
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