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Catheter replacement combined with antiplatelet therapy in hemodialysis catheter-related right atrial thrombus: a potential treatment approach.
BMC Cardiovasc Disord
January 2025
General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, 610041, China.
Background: Catheter-related right atrial thrombus (CRAT) is a severe complication in hemodialysis patients that can lead to catheter dysfunction and pulmonary embolism (PE). However, no standardized treatment strategy currently exists for hemodialysis-related CRAT. This study aims to investigate the efficacy of catheter replacement and antiplatelet therapy in managing hemodialysis CRAT.
View Article and Find Full Text PDFThyroid Function and Morphology in Gaucher Disease: Exploring the Endocrine Implications.
Int J Mol Sci
December 2024
Ward of Endocrinology, Metabolism and Internal Diseases Ward, University Clinical Hospital, 60-786 Poznan, Poland.
Gaucher disease (GD), the most common ultra-rare metabolic disorder, results from lipid accumulation. Systemic inflammation, cellular stress, and metabolic dysfunction may influence endocrine function, including the thyroid. This study evaluated thyroid function and morphology in 60 GD patients, alongside carbohydrate and lipid metabolism.
View Article and Find Full Text PDFPrimary cilia as antennas for oxygen.
Am J Physiol Cell Physiol
February 2025
Institute of Physiology, University Duisburg-Essen, Essen, Germany.
Over the past few decades, the primary cilium, an inconspicuous cell organelle, has increasingly become the focus of current research. The primary cilium is a microtubule-based, nonmotile, antenna-like structure that is present in almost all mammalian cells. The ciliary membrane incorporates a large number of receptor molecules, which further characterize this cellular organelle.
View Article and Find Full Text PDFArticular cartilage regeneration with a microgel as a support biomaterial. A rabbit knee model.
Biomater Adv
March 2025
Center for Biomaterials and Tissue Engineering (CBIT), Universitat Politècnica de València, Valencia, Spain; CIBER de Bioinginiería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Spain.
Articular cartilage has limited regenerative capacity, so focal lesions generate mechanical stress in the joint that induces an aggravation of the damage, which ultimately leads to osteoarthritis. We recently suggested the use of microgels at the site of the cartilage defect, as a support material, to generate a biomechanical environment where pluripotent cells differentiate towards the hyaline cartilage phenotype. Here we propose a chondral regeneration strategy based on subchondral bone injury, and filling the defect site with an agglomerate of two types of microspheres, some rigid made of a biodegradable polyester (40 μm mean diameter), and others with a gel consistency made of platelet-rich plasma obtained from circulating blood (70-110 μm diameter).
View Article and Find Full Text PDFFactors Influencing Immunotherapy Outcomes in Cancer: Sarcopenia and Systemic Inflammation.
Cancer Control
November 2024
Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Article Synopsis
- The study investigates the impact of sarcopenia (muscle loss) and systemic inflammation on the effectiveness of immunotherapy in cancer patients, considering factors like Eastern Cooperative Oncology Group Performance Status (ECOG PS).
- It involved 100 patients who received immune checkpoint inhibitors, analyzing various systemic inflammation markers to evaluate their relationship with overall survival (OS) and progression-free survival (PFS).
- Results show that sarcopenia and hypoalbuminemia are significant factors linked to poorer survival outcomes, suggesting that monitoring sarcopenia could potentially improve patient prognoses, although more research is necessary to confirm these findings.
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