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Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation. | LitMetric
Purpose : To investigate whether irradiated volume of pelvic active bone marrow (BM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation.Methods : Forty-four patients were analyzed and pelvic active bone marrow (BM) was characterized employing FDG-PET. Dosimetric parameters on dose-volume histograms were correlated to nadirs with generalized linear modeling.Results : BM mean dose was significantly correlated to white blood cell (β = -1.338; 95%CI: -2.455/-0.221; p = 0.020), absolute neutrophil count (β = -1.651; 95%CI: -3.284/-0.183; p = 0.048), and platelets (β = -0.031; 95%CI: -0.057/-0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (BM-V-V-Vand-V).Conclusions : FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.
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