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Effect of low androgen levels on IKca and SKca3 channels in rat penile corpus cavernosum. | LitMetric

Effect of low androgen levels on IKca and SKca3 channels in rat penile corpus cavernosum.

Andrologia

Department of Urology, Affiliated Hospital, Southwest Medical University, Luzhou, China.

Published: November 2018

AI Article Synopsis

  • A study was conducted to explore how low androgen levels affect erectile function in rats, focusing on specific potassium channels (IKca and SKca3) in the penis.
  • Thirty-six male rats were divided into groups based on whether they underwent castration and/or received testosterone replacement, and their erectile function was measured over 4 and 8 weeks.
  • Results showed that castrated rats had significantly lower erectile function and reduced expression of IKca, SKca3, and other related proteins, indicating that low androgen levels impair erectile function by affecting these channels and nitric oxide signaling.

Article Abstract

We investigated whether low androgen levels affected erectile function by regulating the expressions of intermediate-conductance Ca -activated K channel (IKca) and small-conductance Ca -activated K channel 3 (SKca3) in corpus cavernous of rats. Thirty-six healthy male SD rats were randomly divided into the 4-week control group, 4-week castration group, 4-week androgen replacement after castration group, 8-week control group, 8-week castration group and 8-week androgen replacement after castration group, respectively. The rats in the androgen replacement groups were subcutaneously injected with testosterone (3 mg/kg) every other day after castration. After 4 and 8 weeks, maximum intracavernous pressure/mean arterial pressure (ICP /MAP) was measured. Expressions of IKca, SKca3, endothelial nitric oxide synthase (eNOS) and P-eNOS in penile corpus cavernosum were detected. ICP /MAP decreased significantly in the castration groups as compared to the control groups and the androgen replacement groups (p < 0.01). mRNA expressions of IKca and SKca3 decreased significantly in the castration groups as compared to the control groups and androgen replacement groups (p < 0.01). Protein expressions of eNOS, P-eNOS, IKca and SKca3 in the castration groups were significantly reduced as compared to the control groups and androgen replacement groups (p < 0.01). Under low androgen levels, ICP /MAP can be reduced by down-regulating the expressions of SKca3 and IKca, inhibiting P-eNOS/eNOS and reducing eNOS bioactivity.

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Source
http://dx.doi.org/10.1111/and.13075DOI Listing

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