There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key uncertainty is whether there is a finite speed limit imposed by the critical role of homeostatic adaptive mechanisms that underpin the efficacy and onset of available psychotropic agents and whether this is mutable with emerging agents with potential rapid onset, in particular ketamine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/0004867418783567 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Top-down curing to construct self-retaining and moisture-pumping double-layered dressing with enhanced antibacterial, hemostatic, and wound healing performances.
Nanoscale
January 2025
Analytical & Testing Center; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610064, China.
Continuous microenvironment modulation is an ongoing challenge in wound dressing, which includes excessive exudate absorption, oxygen delivery, bacterial inhibition and angiogenesis. Herein, we developed an construction strategy to fabricate a self-retaining double-layered wound dressing, where the top layer precursor was composed of Ca-containing polyvinyl butyral (PVB) solution dispersed with hydroxypropyl methylcellulose (HPMC) particles, and the bottom one consisted of sodium alginate (Alg) solution blended with Ag-doped mesoporous bioactive glass powders (Ag-MBG). When in use, both precursors were simultaneously squeezed out from the twin nozzles connected to the individual chambers of a twin-chambered syringe, whereby Ca in the top layer rapidly migrated downwards to crosslink Alg in the bottom layer, leading to the formation of an Alg/Ag-MBG (AA) functional hydrogel for filling an irregular wound.
View Article and Find Full Text PDFComprehensive Identification of Gene Family in Oliv. and Functional Analysis of in Drought Tolerance.
Int J Mol Sci
January 2025
Xinjiang Production & State Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, Alar 843300, China.
The transcription factors in the ABA Response Element Binding (AREB) protein family were differentially regulated under multiple stress conditions; however, functional analyses of AREB in Oliv. had not been conducted previously. In the present study, the comprehensive identification of the gene family and the function of in response to drought stress in were elucidated.
View Article and Find Full Text PDFThe Effect of Continuous Selection in KiwiCross Composite Breed on Breed Ancestry and Productivity Performance.
Animals (Basel)
January 2025
Animal Science Department, Cornell University, Ithaca, NY 14850, USA.
Composite crosses result from the mating of two or more distinct cattle breeds. Breeding performance may improve rapidly using a well-organized composite breeding system and a clear selection index. The KiwiCross is a popular composite cross in New Zealand, combining Holstein-Friesian (high milk production) and Jersey (high milk fat).
View Article and Find Full Text PDFIdentification and Characterization of the Gene Family in Maize, and Its Role Under Biotic and Abiotic Stress.
Biology (Basel)
December 2024
College of Agriculture, Jilin Agricultural Science and Technology College, Jilin 132101, China.
Plant lectin receptor-like kinases (LecRLKs) are plant membrane protein receptor kinases. Lectin-like receptor kinases play a crucial role in regulating plant growth, development, and responses to environmental stimuli. It can rapidly respond to both biotic and abiotic stresses while mediating mechanisms of plant immune responses.
View Article and Find Full Text PDFDiscovery of an Ultralong-acting Nondepolarizing Neuromuscular Blocker That Displays Short Onset Time and On-Demand Rapid Reversal by a Biocompatible Antagonist.
J Med Chem
January 2025
Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.
The combination of ultralong-acting neuromuscular block and subsequent on-demand rapid reversal may provide prolonged surgeries with improved conditions by omitting continuous or repetitive blocker administration, enabling a more stable and predictable hemodynamic profile and eliminating residual block. For this target, we prepared 19 imidazolium-incorporated tetracationic macrocycles. In vivo studies with rats revealed that one macrocycle (IMC-14) displays extremely high blocking activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!