AI Article Synopsis
- Crack cocaine use during pregnancy significantly increases the risk of negative health outcomes for infants, including preterm delivery and low birth weight.
- The study conducted meta-analyses on ten eligible studies to examine the effects of maternal crack cocaine use, finding strong associations with various adverse outcomes.
- Key findings include a notable increase in odds for small for gestational age infants and reduced head circumference, highlighting the urgent need for addressing this public health issue.
Article Abstract
Objective: Crack cocaine consumption is one of the main public health challenges with a growing number of children intoxicated by crack cocaine during the gestational period. The primary goal is to evaluate the accumulating findings and to provide an updated perspective on this field of research.
Methods: Meta-analyses were performed using the random effects model, odds ratio (OR) for categorical variables and mean difference for continuous variables. Statistical heterogeneity was assessed using the I-squared statistic and risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Ten studies met eligibility criteria and were used for data extraction.
Results: The crack cocaine use during pregnancy was associated with significantly higher odds of preterm delivery [odds ratio (OR), 2.22; 95% confidence interval (CI), 1.59-3.10], placental displacement (OR, 2.03; 95% CI 1.66-2.48), reduced head circumference (- 1.65 cm; 95% CI - 3.12 to - 0.19), small for gestational age (SGA) (OR, 4.00; 95% CI 1.74-9.18) and low birth weight (LBW) (OR, 2.80; 95% CI 2.39-3.27).
Conclusion: This analysis provides clear evidence that crack cocaine contributes to adverse perinatal outcomes. The exposure of maternal or prenatal crack cocaine is pointedly linked to LBW, preterm delivery, placental displacement and smaller head circumference.
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| http://dx.doi.org/10.1007/s00404-018-4833-2 | DOI Listing |
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